Through alternative promoter usage, human retinoblastoma protein-interacting zinc finger gene RIZ encodes two different protein products, RIZ1 and RIZ2, which have been identified to be a tumor suppressor and a proto-oncoprotein, respectively. Structurally, the two protein products share the same amino acid sequences except that RIZ2 lacks an N-terminal PR domain with methyltransferase activity...

Cancer is the leading cause of mortality worldwide, and the failure of conventional chemotherapy to effect a major reduction in mortality indicates that new approaches are critically needed. The involvement of free radicals with tumor suppressor genes and proto-oncogenes suggest their role in the development of different human cancers (Bohr et al., 2002). Hence a major portion of the current ph...

The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyiosine or phenflalanine. Decarboxylation gives a phenethylamine building block (C,-...

pistachio has a special ranking among iranian agricultural products. iran is known as the largest producer and exporter of pistachio in the world. agricultural products are imposed under different thermal treatments during storage and processing. designing all these processes requires thermal parameters of the products such as specific heat capacity. regarding the importance of pistachio proces...