Maturation and translation of mRNA in eukaryotes requires the addition of the 7-methylguanosine cap. In vertebrates, the cap methyltransferase, RNA guanine-7 methyltransferase (RNMT), has an activating subunit, RNMT-Activating Miniprotein (RAM). Here we report the first crystal structure of the human RNMT in complex with the activation domain of RAM. A relatively unstructured and negatively cha...

When a sufficient current density passes through the MTJ, the spin-polarized current will exert a spin transfer torque to switch the magnetization of the free layer. This is the fundamental of the novel write mechanism in STT-RAM, current-induced magnetization switching. It allows STT-RAM to have a smaller cell size and write current than MRAM, and also capable of what MRAM promises: fast, dens...

Java Card is now a mature and accepted standard for smart card and SIM technology. Java Card is distinguished primarily by its independence from hardware platforms and portability and is now the most important open standard. However, the main concern of Java Card is now its low execution speed caused by the hardware limitation. In this paper, we propose how to improve a execution speed of Java ...

In multi-label text categorization, one or more labels (or categories) can be assigned to a single document. In many such categorization tasks, there can be correlation on the assignment of subsets of the set of categories. This can be exploited to improve machine learning techniques devoted to multi-label text categorization. In this paper, we examine a Virtual Generalizing Random Access Memor...

approved: Redacted for privacy Philip D. Whanger Following initial intramuscular injections of 500 pCi 75 Se, semen was collected periodically by electroejaculation over a 63 day period from a selenium-deficient and a selenium-adequate ram. Ten and three days prior to necropsy, second and third injections of 500 11Ci were given. Testes, accessory glands, and semen were obtained from a bull inje...

Objective(s) The possible risks of radio-frequency electromagnetic fields (EMF) for the living organisms and human body are a growing concern for our society. In this study, we examined the possibility of changes in working memory and hippocampal histological characteristics effects in mice brain following whole body exposure to microwave radiation. Materials and Methods During gestation per...

two experiments were designed to examine the effects of crude seminal plasma (csp) exposure ofejaculated and epididymal spermatozoa before freezing. experiment 1, two consecutive ejaculates werecollected (n=4) within 5 min, the second one was carried out in a tube containing fiser extender (coatedspermatozoa); by centrifugation, seminal plasma was removed from coated ejaculates. the pellets wer...

Saccharomyces cerevisiae RAM is a conserved signaling network that regulates maintenance of polarized growth and daughter-cell-specific transcription, the latter of which is critical for septum degradation. Consequently, cells defective in RAM function (designated ramDelta) are round in morphology, form feeble mating projections, and fail to separate following cytokinesis. It was recently demon...

Understanding how cell division and cell elongation influence organ growth and development is a long-standing issue in plant biology. In plant roots, most of the cell divisions occur in a short and specialized region, the root apical meristem (RAM). Although RAM activity has been suggested to be of high importance to understand how roots grow and how the cell cycle is regulated, few experimenta...

Eddy current (EC) estimate of flaw size obtained from inservice inspection is often the primary means of assessing the structural integrity of steam generator tubes. Reliable prediction of failure pressure and leak rate in tubes with complex cracking requires more detailed information about the geometry and extent of degradation than is generally available from conventional bobbin coil examinat...