A dimeric neomycin-neomycin conjugate 3 with a flexible linker, 2,2'-(ethylenedioxy)bis(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT-rich DNA duplexes with high affinity. Biophysical studies have been performed between 3 and different nucleic acids with varying base composition and conformation by using ITC (isothermal calorimetry), CD (circular dichro...

BACKGROUND Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS We studied patients with septic shock requiring vasopressor, newly admitted to the intensive care un...

The metastable conformational states which underlie the hysteresis displayed by Escherichia coli ribosomal RNA in its pH titration in the acid range have been analyzed in terms of acid-stable RNA secondary structures. Sedimentation measurements show that the phenomenon is ktramolecular, so that analysis of the hysteresis loops can, in principle, reveal details of molecular architecture. Hystere...

abstract phosphate is an essential element for plants, animals, and human. mobility and availability of phosphate in the natural systems is controlled by the adsorption-desorption and dissolution-precipitation reactions. iron (hydr)oxides including goethite play an important role in phosphate adsorption reactions in soil. surface area, crystallinity, and morphology of iron (hydr)oxides are the ...

Models for humic and fulvic acids are discussed based on 13 C liquid state NMR spectra combined with results from elemental analysis and titration studies. The analysis of NMR spectra is based on a full reconstruction of the NMR spectrum done with help of 13 C-NMR data bases by adding up chemical shifts of all substructures from the proposed models. A full reconstruction makes sure that all car...

An automated analyzer was developed to achieve fast, precise, and accurate measurements of seawater total alkalinity (AT) based on single-point titration and spectrophotometric pH detection. The single-point titration was carried out in a circulating loop, which allowed the titrant (hydrochloric acid and bromocresol green solution) and a seawater sample to mix at a constant volume ratio. The di...

A new acid -base indicator which is less hazardous and inexpensive is proposed. It is capable of d istinguishing between the acids and bases. Titrations were carried out to ensure that the proposed indicator yields quantitative results. The results of titrations were quite satisfactory. The indicator was giving a distinct sustained colour even in the case of weak base and weak acid titrations. ...

Objective: Garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. Infectious bronchitis virus (IBV) is a coronavirus. The available vaccines against IBV cannot cover new variants. This study evaluated the inhibitory effects of garlic extract on IBV.  Materials and Methods: The constituents of garlic extract were detected by gas chromatography. This study was d...