To further investigate the molecular basis underlying the dysregulation of B cell homeostasis associated with bovine leukemia virus disease progression in cattle, bovine bax was cDNA cloned and sequenced. The predicted amino acid sequence of bovine Bax revealed a 192-amino-acid protein having extensive identity with the human (97%), murine (93%), and rat (94%) homologues. Because the ratio of B...

The aim of this study was to investigate the activity apoptosis and autophagy in animals (cows, horses, donkeys, dogs cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, qPCR. mRNA transcript levels caspase-3, Bax, Bcl2 LC3B were determined Caspase-3 AIF immunopositivity not observed immunohistochemical immunofluorescence staining, whereas intensively compare...

Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, involvement phosphatase tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway process.
 Methods: Human cell line SV-HUC-1 human T24 were randomly assigned to blank control group groups. Protein expression levels apoptosis-related factors (Bcl-2, Bax, caspase-3] ...

background and objective: as apoptotic cell death is extremely involved in physiological development and many pathological situations such as cancer and neurodegenerative diseases, the understanding of its molecular machinery can be useful in designing new therapeutic strategies. the present study investigated the temporal expression of the proapoptotic protein bax in adult spinal motoneurons. ...

BACKGROUND The retinoblastoma protein (RB) is an important cell cycle regulator. RB also plays an important role in the regulation of apoptosis, which is mediated by interaction of p53 signaling mediators. The present study was designed to assess the clinicopathological significance of RB and p53 pathway-related proteins (p53, p21WAF1/CIP1 and Bax) expression in resectable invasive ductal carci...

Purpose Many anticancer drugs induce apoptosis in malignant cells, and resistance to apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, respectively. Both Bax and Bcl-2 as well as their ratio have been regarded as prognostic markers in various can...

BACKGROUND/AIMS This study had three aims. The first was to determine whether Bax (Bcl-2-associated X protein) and AIF (apoptosis-inducing factor) are expressed in tissue sections of colorectal tumors. The second was to ascertain whether there is any difference in Bax and AIF expression between colorectal polyps, adenomas, and carcinomas. The third aim was to determine whether there is any diff...

Background: Wogonin as a flavonoid compound is known for its anticancer effect through growth control, differentiation, and apoptosis. This study investigates the possible activity of wogonin in inducing cell death breast tumors MDA-MB231. Materials Methods: The level proliferation was evaluated by MTT assay. Cycle analysis apoptotic rate were assessed flow cytometry. mRNA Bax, Bcl-2, p53, surv...

The mammalian inducer of apoptosis Bax is lethal when expressed in yeast and plant cells. To identify potential inhibitors of Bax in plants we transformed yeast cells expressing Bax with a tomato cDNA library and we selected for cells surviving after the induction of Bax. This genetic screen allows for the identification of plant genes, which inhibit either directly or indirectly the lethal phe...

Bcl-2, Bcl-x and Bax are members fo a family of cytoplasmic proteins that influence cell survival. Whereas increased expression of Bcl-2 or Bcl-x promotes cell survival following withdrawal of survival factors, increased expression of Bax is thought to suppress survival. To investigate the potential roles of these proteins in regulating the survival of developing neurons, we compared the effect...