Glioblastoma (GBM) is an incurable cancer, with mean post-diagnosis survival time of 14-16 months. Metagenomic analysis by The Cancer Genome Atlas (TCGA) program has identified microRNA-182-5p (miR-182-5p or miR-182) as the only miRNA associated with favorable disease prognosis and temozolomide (TMZ) susceptibility. Previous reports have indicated that miR-182 down regulates expression of BCL2L...

PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are recognized and differentially dephosphorylated is unclear. Using phosphoproteomics combined with kinetic modeling to extract B55-dependent rate constants, we have systematically identified B55 substrates and assigned their temporal order in ...

BACKGROUND/AIM This study aimed to define the frequency of a primitive reflex, the buccopalpebral reflex (BPR), and its association with the clinical situation in patients with Parkinson disease. MATERIALS AND METHODS Between May 2010 and May 2011, 222 patients, 115 with Parkinson disease and 107 patients without any sign of neurodegenerative disease, were included in the study. All included ...

Recent studies show that regulatory T cells (Tregs) play an essential role in tolerance induction after organ transplantation. In order to examine whether there are differences in the composition of the total CD4(+)CD127(low+/-)FoxP3(+)- Treg cell pool between stable transplant patients and patients with biopsy proven rejection (BPR), we compared the percentages and the functional activity of t...

Business process re-engineering (BPR) is the main way in which organizations become more efficient and modernize. It transforms an organization in many different ways and can directly have an impact on the performance of an organization. Even though many Saudi technical and vocational training agencies are employing e-Learning strategies, Saudi schools and educational systems are still relying ...

The managerial and organization practices required by an increasingly dynamic competitive manufacturing, business, and industrial environment include the formation of “virtual enterprises.” A major concern in the management of virtual enterprises is the integration and coordination of business processes contributed by partner enterprises. The traditional methods of process modeling currently us...

Addressing to improve the trustworthiness of Business Process Re-engineering (BPR) system, this paper proposes a trustworthy construction approach to solve the problem mentioned above. Firstly, we analyze related literatures about the topic, we realize that main reason causing to reduce trustworthiness of BPR system is due to break of trustworthy connectivity between front configuration tools a...

Successful Project Management (PM) comes from the combination of skills, knowledge, tools and techniques to strategically plan, execute and control projects with a variety of requirements and constrains. In recent years, there has been an increased interest in implementation methodologies that not only allows successful PM, but integrates Product Lifecycle Management (PLM), Business Process Mod...

In today’s business world with rapid change and global expansion, the trends are also changing. Companies are shifting from product centered approach to customer oriented approach. Therefore the priorities are also changing and the companies are trying to satisfy their customers to deliver what they want in terms of values. Thus, to meet customer’s need and expectation and to get competitive ad...