نتایج جستجو برای: benzamidobenzoic acid hydrazide
تعداد نتایج: 748241 فیلتر نتایج به سال:
S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...
There have been several demonstrations of the limited tumorigenicity of INH in mice. The 1st such experiment was re ported by Juhász et al. (3, 4), who reported the induction of pulmonary adenomas, lymphomas, and leukemia.s in randomly bred mice injected i.p. with INH. In a subsequent study these same investigators found only an induction in lymphomas and leukemias but reported the occurrence ...
General. Linkers used in preparation of modified hyaluronan (HA) derivatives were synthesized according to stated literature procedures. Their structures are given in Scheme S1. Particularly, 3,3'dithiobis(propionic hydrazide) 11 and 2-(2-pyridinyldithio)ethyl hydrazinecarboxylate 32 were used to attach thioland 2-dithiopyridyl-terminated side chains to HA backbone respectively. 3-(Acrylamido-1...
Some new thiazolidines and spirothiazolidines derived from hydrazones of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative of isoniazid, were synthesized and characterized by analytical, IR, (1)H- and (13)C-NMR and mass spectral data. Some of the newly synthesized compounds were screened for their antimycobacterial activities. None of the tested compounds sho...
The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the...
A series of substituted 1,3,4-oxadiazole derivatives 2a-e and 4a-e have been synthesized from diphenyl acetic acid hydrazide under various reaction conditions. These compounds have been tested in-vivo for their anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-chloro-4-fluro-phenyl)acetamide 4b has emerged as the most active compou...
We describe a novel two-step approach for the synthesis of compounds with hydroxyl-amide group (hydroxamic acids), which are widely known their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is N-substituted succinimide via reaction aromatic amine or carboxylic acid hydrazide succinic anhydride. second step involves imide r...
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