The environment is heavily populated with polycyclic aromatic hydrocarbons (PAHs), which are dangerous to human health. Degradation and cleaning of PAH chemicals from water soil regions crucial due their chemical biological impacts persistent nature. In this study, we found that a very efficient bacterial consortium A-LOBP-19A+LOP-9 (99.62%) for benzo[a]pyrene up 1000ppm B-LOP-9 +GWP-2 (93.8%) ...

An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(«)pyrene (BP) tetrols released after acid hydrolysis of lung DN A from lung cancer patients, so that the formation of benzo(a)pyrene diol-epoxide-DNA adducts can be measured. The r-7,c-10,f-8,f-9-tetrahydroxy-7,8,9,10-tetrahydro-BP isolated by high-performance liquid chromatograph...

an efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. the procedure employs a three-component condensation reaction in one-pot using 2h-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence of catalytic amount of l-prolinein aqueous media.

Distribution ratios and sources of polycyclic aromatic hydrocarbons (PAHs), including Fluoranthene (Flt), Pyrene (Pyr), Benzo(a)pyrene (BaP), Benzo(k)fluoranthene (BkP), Indeno(1,2,3-cd)pyrene (IP), Benzo(ghi)perylene (BgP) in urban surface and subsurface soil collected from Riyadh city, Saudi Arabia was studied. The sum of the six PAHs ranged from 30.5-1016.6 ng g -1 with an average of 286.6 i...

The tumorigenicity of two coal tar mixtures was compared to that of benzo[a]pyrene after 2 years of feeding. Mixture 1, a composite of coal tar from seven coal gasification plant waste sites, was fed to female B6C3F1 mice (48 mice per group) for 2 years at doses of 0.0, 0.01, 0.03, 0.1, 0.3, 0.6 and 1.0%. Mixture 2, which was composed of coal tar from two of the seven waste sites and another si...

A rapid and inexpensive method has been developed to estimate rates of benzo(a)pyrene phenol production by per fused rat liver. This method is based on the measurement of benzo(a)pyrene phenols utilizing a simple fluorometric proce dure. Within 2 to 3 min after infusion of benzo(a)pyrene bound to serum albumin, phenols are excreted into the perfusate, primarily as glucuronide and sulfate conjug...

The formation of adducts of benzo(a)pyrene metabolites on DNA was investigated in endometrial tissue from humans, hamsters, mice, and rats. anti-Benzo(a)pyrene-7,8-diol-9,10-epoxide was the predominant adduct identified in all the species studied. The amount of (+)-anti-benzo(a)pyrene-7,8-diol-9,10-epoxide bound to DNA from human endometrium was approximately 3 times higher than to DNA from ham...

The oral cancer potencies of six polycyclic aromatic hydrocarbons (benzo[b]fluoranthene, benzo[j]fluoranthene, chrysene, dibenzo[a,h]pyrene, dibenzo[a,i]pyrene, and 5-methylchrysene) were estimated from cancer dose-response data obtained from animal studies. Potency estimates obtained from newborn mouse intraperitoneal (i.p.) injection studies were converted to oral equivalent potencies. The co...

Arene oxide derivatives of carcinogenic polycyclic hydro carbons have been postulated as the reactive intermediates responsible for the in vivo binding of the parent hydrocar bon to cellular nucleic acids. In this study the reaction of 12 different Kand non-K-region arene oxides and 7 benzo(a)pyrene phenols with polyguanylic acid in aqueous acetone solutions has been investigated. The extent of...

The nal¨ve library from the lymphocytes of healthy humans was screened by murine single-stranded idiotypic antibodies against benzo[a]pyrene (pSh). The phage clone which contained of anti-idiotypic antibody against benzo[a]pyrene, designated as A4, was chosen for further work because of highly specific to pSh. The available protein databases were searched. The A4 amino acid sequence was unique ...