Fluorine-19 magnetic resonance imaging ((19)F MRI) probes enable quantitative in vivo detection of cell therapies and inflammatory cells. Here, we describe the formulation of perfluorocarbon-based nanoemulsions with improved sensitivity for cellular MRI. Reduction of the (19)F spin-lattice relaxation time (T1) enables rapid imaging and an improved signal-to-noise ratio, thereby improving cell d...

The first mercury-catalyzed synthesis of 1,2-diketones by alkyne oxidation has been developed. This inexpensive method extends the potential mercury catalysis and allows rapid construction various α-carbonyl amides in good yields with high functional group tolerance.

A new series of oxovanadium (IV) tetraazamacrocyclic complexes type [VO(mac)]SO4, have been synthesized via in situ reaction 1,8-diaminonaphthalene and substituted β-diketones (1-phenyl-3-(phenyl/4-chlorophenyl/4-hydroxyphenyl/4- methoxyphenyl/4-nitrophenyl)-diketone) the presence oxovanadium(IV) sulphate methanol. Attempts to synthesize corresponding metal free macrocyclic ligands did not prov...

The selective synthesis of different products from the same starting materials in water, which is the most abundant solvent in nature, is a crucial issue as it maximizes the utilization of materials. Realizing such reactions for ketones is of considerable importance because numerous organic functionalities can be obtained via nucleophilic addition reactions. Herein, we report chemoselective red...

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.