To cite: Bonnecaze AK. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2015-212911 DESCRIPTION A 41-year-old African American woman with no significant medical history presented to clinic reporting of episodic finger numbness and colour changes. She described feeling as if her fingers were frostbitten and noted her second, third and fourth digits appeared white d...

Objective: Beraprost sodium (BPS), a prostacyclin (PGI ) analogue, has been reported to exhibit beneficial effects on atherosclerosis 2 in both human and animal models. To clarify the underlying mechanism, we investigated the effects of BPS on neointimal formation after balloon injury in the canine coronary artery. Furthermore, we determined its anti-atherosclerotic effects in cultured smooth m...

OBJECTIVES To investigate whether the combination of an oral endothelin (ET)-A receptor antagonist and an oral prostacyclin(PGI2) analogue is superior to the single use of each drug alone for treating pulmonary hypertension(PH). BACKGROUND Treatment with intravenous PGI2 or an ET-A receptor antagonist was effective for PH; however, the effect of both administrations is unclear. METHODS We a...

It is widely accepted that the inhibition of gastric motor activity as well as the maintenance of gastric mucosal blood flow and mucous secretion are important for the homeostasis of the gastric mucosa. The present study was performed to ascertain whether or not endogenous PGs, which can protect the stomach from noxious stimuli, affect gastric motor activity and emptying. The myoelectrical acti...

OBJECTIVES We sought to investigate whether the combination of an oral endothelin (ET)A receptor antagonist and an oral prostacyclin (PGI(2)) analogue is superior to the single use of each drug alone for treating pulmonary hypertension (PH). BACKGROUND Treatment with intravenous PGI(2) or an ET(A) receptor antagonist was effective for PH; however, the effect of both agents is unclear. METHO...

Abstract Pulmonary arterial hypertension (PAH) is a rare and severe disease characterised by the progressive narrowing of small pulmonary arteries resulting in right-sided heart failure. Despite advances treatment, some PAH patients require lung transplantation, which carries risks long-term complications. We report case male patient with no significant comorbidities, who developed dyspnoea on ...