The aim of this study was to analyze the effect of immunomodulatory treatment of multiple sclerosis (MS) on lymphocyte surface immunomarkers. The special attention was given to TCR alpha/beta, gamma/delta and alpha/beta HLA-DR markers. Peripheral blood was obtained from 39 patients with clinically definite R-R MS, fulfilling the criteria of McDonald et al.[5]. The group of 15 patients was treat...

A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant hu...

human interferon β (inf-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. in this study an expression vector was designed and constructed for expression of human inf-β-1b either in shake flasks and bench top bioreactor. the designed vector was constructed based upon pet-25b(+) with t7 promoter. recombinant human beta interferon ...

Interferon beta (IFNb) preparations are commonly used as first-line therapy in relapsing-remitting multiple sclerosis (RRMS). They are, however, characterized by limited efficacy, partly due to the formation of anti-IFNb antibodies in patients.In this pilot study, we assessed with the ELISA method the presence of the binding antibodies (BAbs) against interferon beta after 2 years of therapy wit...

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 month. Here, we share the findings and the management of intermediate uveitis and retinal periphlebitis in an MS case being treated with interferon...

Beta interferon − INF 1b: Betaferon® and Extavia® (vial 250 g) INF 1a: Avonex® (vial 30 g); Rebif® (vial 22–44 g). Both also in syringes and preloaded containers. RR MS Pseudo-fever syndrome, depression, psychiatric disorders, moderate myelosuppression, hypotension, high liver enzymes, cough, dyspnea, proteinuria, OHT, hyperuricemia, KI, neuropathy, confusion, edema, hair loss, digestive altera...

abstract        background and objective: this study was conducted to evaluate epidemiology of risk factors for hepatitis c virus (hcv) transmission, and determine the association of its genotypes with viral load and response to treatment in patients referred to the infectious disease clinic of khorramabad.         methods: the study included patients infected with hepatitis c referred to the i...

BACKGROUND Adherence to disease-modifying drugs (DMDs) is one of the key factors for achieving optimal clinical outcomes. Rebismart® is an injection device for subcutaneous administration of interferon beta-1a (INF β-1a) that is also able to monitor adherence objectively. The aim of this study was to describe adherence to INF β-1a using the said electronic autoinjection device and to explore th...