From CH2Cl2 and MeOH extracts of the stems of Cynomorium songaricum RUPR. (Cynomoriaceae), ursolic acid and its hydrogen malonate were isolated as inhibitors of human immunodeficiency virus type 1 (HIV-1) protease, with 50% inhibitory concentrations (IC50) of 8 and 6 microM, respectively. Amongst various synthesized dicarboxylic acid hemiesters of related triterpenes, inhibitory activity tended...

Bryonolic acid (BrA) is a pentacyclic triterpene present in several plants used in African traditional medicine such as Anisophyllea dichostyla R. Br. Here we investigated the in vitro anticancer properties of BrA. We report that BrA inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the chole...

Abstract The genus Diospyros comprises numerous plant species, several of which are economically and ethnomedicinally important. Some them yield valuable timber, some give commercialized edible fruit. plants have long been known for their therapeutic property employed in folk medicine different parts the world. Phytochemical study these might information beneficial utilization. gracilis is one ...

1Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2Department of Physiology, Student Research Committee of Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran 3Cell and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Scie...

BACKGROUND There are no known studies that have examined β-alanine supplementation in military personnel. Considering the physiological and potential neurological effects that have been reported during sustained military operations, it appears that β-alanine supplementation may have a potential benefit in maintaining physical and cognitive performance during high-intensity military activity und...

The tumor-producing effect of dibenz(a,h)anthracene led Cook (5) to undertake experiments showing that 9-isopropyl BA is a (weak) carcinogenand Fieseret aL (9) synthesized the stronger cancer-producing substances 7-methyl-BA and 7,8-DMBA. Considerably later it was found that 7,12-DMBA (1), 7,8,12-TMBA (1), and 6,7,8-TMBA (21) are very powerful carcinogens. It was evident that substitution of BA...