BACKGROUND Vaginal atrophy is a common complication in menopause which does not improve with time and, if untreated, can affect the quality of life for women. The aim of this study was to compare the effectiveness of the vaginal cream of hyaluronic acid and conjugated estrogen (Premarin) in treatment of vaginal atrophy. METHODS This study was a randomized controlled clinical trial on 56 menop...

Intra-articular hyaluronic acid viscosupplementation is gaining popularity as a treatment option in the nonoperative management of patients with osteoarthritis. Recent clinical studies have demonstrated that the anti-inflammatory, anabolic, and chondroprotective actions of hyaluronic acid reduce pain and improve patient function. With evidence mounting in support of the efficacy of this treatme...

OBJECTIVE to evaluate the efficacy of hyaluronic acid in the post-operative of knee arthroscopy. METHODS we have evaluated 49 patients undergoing arthroscopic procedure with the use of intra-articular hyaluronic acid (Group 1) and 49 patients undergoing arthroscopic procedure without the use of hyaluronic acid (Group 2). Patients were evaluated based on the Visual Analogue Scale, household an...

Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, ...

Previous work pointed out the possibility to enhance the nutritional value of meat products using long chain omega-3 PUFA enriched emulsions. Oil-in-water emulsions elaborated with a mixture of algae and linseed oils (15:10) in order to be used as functional ingredient were stabilized with BHA (butylhydroxyanisol) or with a lyophilized water extract of Melissa officinalis L. (Lemon balm). The l...

Natural antioxidants have gained considerable interest in recent years for their role in preventing the auto oxidation of fats, oils and fat containing food products. In the present study, three plant foods viz., amla (Emblica officianalis), drumstick leaves (Moringa oleifera) and raisins (Vitis vinifera) were used as sources of natural antioxidants. All the three extracts exhibited a high perc...

The activation of scheelite and wolframite by lead nitrate with benzohydroxamic acid (BHA) as collector was investigated by means of micro flotation test, zeta potential measurement, X-ray photoelectron spectroscopy (XPS) analyses and density functional theory (DFT) calculation. The flotation results confirmed that the addition of lead nitrate can markedly enhance the recovery of scheelite and ...

UsingMedicare Data to Understand Low-Value Health Care: The Case of Intra-articular Hyaluronic Acid Injections The US Food and Drug Administration first approved intraarticularhyaluronicacid injections (alsoknownasviscosupplementation) in 1997 to treat patients with severe knee osteoarthritis. The effectiveness of these injections, however, has recently been questioned. In 2013, the American Ac...

OBJECTIVES In this study, we aimed to study the anti-apoptotic effects of hyaluronic acid on the apoptotic effects of bupivacaine in cultured rat chondrocytes in a time and dose-dependent manner. MATERIAL AND METHODS The rat chondrocytes were treated with 7.69 µM, 76.9 µM, and 384.5 µM bupivacaine and 50 µg/ml hyaluronic acid concentrations for six, 24, and 48 hours. At the end of the treatme...

LTHOUGH A VAST AMOUNT OF LITERATURE has been published in recent years on the subject of hyaluronic acid and hyaluronidase, owing to the importance of a biologic function which has been ascribed to these two substances, no satisfactory method yet exists for the determination of minute quantities of hyaluronic acid or other mucopolysaccharides. Various mucopolysaccharides form stable dispersions...