Etoricoxib is an anti-inflammatory drug largely used in a variety of acute and chronic inflammatory diseases, but is associated with low aqueous solubility and poor dissolution leading to a delayed rate of absorption and onset of action. This study focuses on the development and pharmacological evaluation of a series of binary systems of etoricoxib with cyclodextrins. The binary systems of etor...

Removal of selenium oxyanions by the binary oxide systems, Al- or Fe-oxides mixed with X-ray noncrystalline SiO(2), was previously not well understood. This study evaluates the adsorption capacity and kinetics of selenium oxyanions by different metal hydroxides onto SiO(2), and uses X-ray absorption spectroscopy (XAS) to assess the interaction between selenium oxyanions and the sorbents at pH 5...

Protonation constants for the biologically-important thioamino acids cysteine (CSH), penicillamine (PSH) and glutathione (GSH), and the formation constants of their complexes with Cu(I), have been measured at 25 °C and an ionic strength of 1.00 mol dm(-3) (Na)Cl using glass electrode potentiometry. The first successful characterisation of binary Cu(I)-CSH and Cu(I)-GSH species over the whole pH...

Dihydrofolate reductase has been isolated and purified to homogeneity in g6od yield from two trimethoprim-resistant strains of Escherichia coli K12, strains MB 3746 and MB 3747. The two enzymes are closely related to one another and to the dihydrofolate reductase from E. coli MB 1428. The 3746 and 3747 reductases both exhibit an apparent molecular weight of 17,500 with almost identical amino ac...

We present new proofs of the additivity, resolution and cofinality theorems for the algebraic K-theory of exact categories. These proofs are entirely algebraic, based on Grayson’s presentation of higher algebraic K-groups via binary complexes. 2000 Mathematics Subject Classification: 19D99

The enzyme 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (KDO8PS) catalyses the condensation of arabinose 5-phosphate (A5P) and phosphoenol pyruvate (PEP) to obtain 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P). We have elucidated initial modes of ligand binding in KDO8PS binary complexes by X-ray crystallography. Structures of the apo-enzyme and of binary complexes with the substrat...

When [14C]glucose is mixed with yeast hexokinase and subsequently diluted with 0.18 rnM MgATP and a large amount of unlabeled glucose, half of the enzyme-bound [14C]glucose is converted to glucose-6-P prior to dissociation. At higher concentrations of ATP, all of the bound [14C]glucose is trapped as glucose-6-P indicating that: the binary complex is fully functional and that the ternary complex...

The conformation of NADP+ in glucose-6-phosphate-dehydrogenase--NADP+ binary complexes has been investigated using proton-proton transferred nuclear Overhauser enhancement measurements to determine interproton distance ratios between bound NADP+ protons. The enzymes from Saccharomyces cerevisiae (brewer's yeast and baker's yeast) and Hansenula jadinii (Candida utilis, Torula utilis) form binary...