p38α is considered as the key isoform involved in modulating inflammatory response in rheumatoid arthritis and inflammatory pain and is therefore a key target for compound screening in pharmaceutical industry. In this study we demonstrate the use of Microscale Thermophoresis to perform an essentially label-free measurements of small molecule binding to protein targets by using a competitive app...

Abstract Recently, nanotechnology has been effectively used in the field of road pavement. Oxidation and aging asphalt cause deterioration pavements increase asphalt-related emissions. We propose an anti-aging strategy to interrupt by using engineered clay/fumed silica nanocomposites. In this research, morphological, chemical, thermal, mechanical, rheological properties nano-modified binders ar...

Abstract The RILEM TC 272 PIM (Phase and Interphase behavior of innovative bituminous Materials)—TG1 Binder has initiated an inter-laboratory program investigating the phase interphase behaviour binders. Within scope, four laboratories evaluated low temperature properties seven binders with differential scanning calorimetry (DSC). DSC been accepted as a powerful tool to evaluate, among others, ...