The presence of active copper- and zinc-containing superoxide dismutase in isolates of the cryptic genospecies of Haemophilus, responsible for urogenital, neonatal, and mother-infant infections, can be used as a biochemical marker to discriminate them from H. influenzae sensu stricto strains.

IMPORTANCE Biochemical markers of disease allow clinicians to monitor disease severity, progression, and response to treatment. C-reactive protein and erythrocyte sedimentation rate are commonly used biochemical markers of inflammatory disease. We present 2 cases that indicate that D-dimer levels may be useful as a potential biochemical marker of disease activity in certain cutaneous inflammato...

Specific biochemical changes occurring during hepatocarcinogenesis have been sought by many investigators. The development of multistage models for hepatocarcinogenesis in the rodent has renewed interest in such marker alterations in preneoplastic as well as neoplastic hepatocytes. Preneoplastic altered hepatic foci (AHF) exhibit specific histomorphologic changes as viewed with tinctorial stain...

Aberrant promoter methylation is known to silence tumor-suppressor genes in prostate cancer (PCa). We correlated quantitative promoter methylation levels of APC, TGFβ2 and RASSF1A in 219 radical prostatectomies diagnosed between 1998 and 2001 with clinicopathological follow-up data available including Gleason Pattern (GP), Gleason Score (GS) and pathological stage and explored their potential i...

Birth asphyxia is a leading cause of neonatal mortality in India. At present there is no reliable early marker to predict the outcome in these cases. We conducted this study to evaluate 8-hydroxy 2-deoxyguanosine (8-OHdG) as a biochemical marker for predicting outcome in perinatal asphyxia. Term neonates fulfilling the inclusion criteria were recruited in the study. Cord blood was collected imm...

Bacteremia due to multiply-antibiotic-resistant Serratia marcescens occurred within 1 week in four patients who were in adjacent beds in an intensive care unit. The strains were serotyped as O14:H12 and were nitrate negative. This unusual biochemical marker was useful in the investigation of the outbreak.

The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related out...

INTRODUCTION Although prostatitis is a common male urinary tract infection, clinical diagnosis of prostatitis is difficult. The developmental mechanism of prostatitis is not yet unraveled which led to the elaboration of various biomarkers. As changes in asparagine-linked-(N-)-glycosylation were observed between healthy volunteers (HV), patients with benign prostate hyperplasia and prostate canc...

BACKGROUND/AIM Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated. METHODS TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding (>1 week) retinal detachment (n = 29), fresh...

An extensive survey of markers for transformation of adult rat liver-derived epithelial-like cell lines was conducted. The cell surface properties associated with tumorigenicity were reported earlier. Now we report the correlation of various growth characteristics and enzyme activities with tumorigenic ity. Among markers identified that correlated with tumorigenic ity within the population, bio...