A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA) bolt as the bone anchor and a poly(D,L-lactide-co-glycolide) (PLGA) nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon-bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured afte...

BACKGROUND AND AIM: An important goal of periodontal plastic surgery is the creation of attached gingiva around the teeth. In this study, the aims were to culture gingival fibroblasts in a biodegradable scaffold and measure the width of attached gingiva after the clinical procedure.METHODS: This study was carried out on 4 patients (8 sites), with inadequate attached gingiva next to at least two...

Congenital cardiac anomalies represent the most common birth defect affecting nearly 1% of all live-births. Severe forms of congenital heart disease are life-threatening and require surgical intervention. Despite significant advances in the surgical and medical management of this disease, it remains a leading cause of death in the newborn period and lifelongmorbidity for survivors. One signific...

In medicine, objects that need to be removed later such as stents are commonly placed in patients, with the time of removal dependent on progress of the patient. In these cases biodegradable materials that last for a specific time may not be suitable. We propose a new class of nanostructured materials that can hold their form as long as wanted, Triggered, Nanostructured Biodegradables (TNBs), t...

This article provides more experimental details and findings of the study as to how the elasticity of scaffold material modulates the gene expression of annulus fibrosus-derived stem cells (AFSCs) (Zhu et al., 2015 [1]). The detailed synthetic route and characterizations of four kinds of biodegradable poly(ether carbonate urethane)ureas (PECUUs) are described. After AFSCs were cultured on elect...

In tissue engineering, porous biodegradable scaffolds are used as templates for regenerating required tissues. With the advances in computational tools, many modeling approaches have been considered. For example, fluid flow through porous medium can be modeled using the Brinkman equation where permeability of the porous medium has to be defined. In this review, we summarize various models recen...

To tackle tissue vascularization, a robust 3-D micro-patterning technique was developed to create complex bioscaffolds from a synthetic biodegradable elastomer (Poly(octamethylene maleate (anhydride) citrate) by pre-patterning, solidifying, and stamping thin polymer sheets layer-by-layer to form intricate micro-structures. The bio-scaffold contains an 3-D perfusable branched network which suppo...

Hydrogels have many different applications in the field of regenerative medicine. Biodegradable, injectable hydrogels could be utilized as delivery systems, cell carriers, and scaffolds for tissue engineering. Injectable hydrogels are an appealing scaffold because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, ...

At the Freiburger Materialforschungszentrum we have developed a new process (3DBioplotting) that permits most kind of polymers and biopolymers to be used in 3D scaffold design, including hydrogels (e.g. collagen, agar), polymer melts (e.g. PLLA, PGA, PCl) and twocomponent systems (e.g. chitosan, fibrin). Cells can be incorporated within the construction process, making this an ideal Rapid Proto...

Background: This study addressed the development of biodegradable and biocompatible scaffolds with enhanced biomechanical characteristics. The biocompatibility and the cationic nature of chitosan (CTS) make it more effective as a bone grafting material. Methods: The hydroxyapatite nanoparticles (nHA) were synthesized by hydrothermal method, and bioglass (nBG) (50% SiO2-45% CaO-5% P2O5) was synt...