Worldwide, increasing numbers of patients are developing end-stage renal disease, and at present, the only treatment options are dialysis or kidney transplantation. Dialysis is associated with increased morbidity and mortality, poor life quality and high economic costs. Transplantation is by far the better option, but there are insufficient numbers of donor kidneys available. Therefore, there i...

Repair of tooth supporting alveolar bone defects caused by periodontal and peri-implant tissue destruction is a major goal of reconstructive therapy. Oral and craniofacial tissue engineering has been achieved with limited success by the utilization of a variety of approaches such as cell-occlusive barrier membranes, bone substitutes and autogenous block grafting techniques. Signaling molecules ...

This review addresses the issue of bioengineering of artificial lymphoid organs.Progress in this field may help to better understand the nature of the structure-function relations that exist in immune organs. Artifical lymphoid organs may also be advantageous in the therapy or correction of immunodefficiencies, autoimmune diseases, and cancer. The structural organization, development, and funct...

This work studied simultaneous removal of ammonium and potassium ions by ion exchange with the natural zeolite clinoptilolite. Synthetic and real RO permeate used in experiments contained approximately 250 mg NH4/L and 200 mg K/L. The real RO permeate was obtained from membrane treatment of anaerobically digested cattle manure effluents. Batch experiments were conducted to determine ammonium an...

results utilizing autologous stem cell populations to treat craniofacial defects is a promising field of ongoing investigations. studies show that cartilage stem/progenitor cells (cspcs) are highly chondrogenic and can produce elastic reconstructive material with long-term tissue restoration. conclusions auricular reconstruction surgery is a challenging plastic procedure that requires great exp...

The Vanderbilt-Northwestern-TexasHarvard/MIT Engineering Research Center for Bioengineering Educational Technologies (VaNTH) is an ERC aimed at developing a new approach to bioengineering education. The goal of the VaNTH ERC is to integrate learning science, learning technology, assessment and the domain subjects of bioengineering into a new paradigm for the education of bioengineers. VaNTH has...

A long historical experience of monofrequency rheoencephalography (REG) showed its limited capabilities. The new approach is presented – multifrequency REG that is REG recording simultaneously at three frequencies 16, 100 and 200 kHz. The different brain impedances received were analyzed on the base of equivalent electrical circuits of brain tissue. First, this enables to calculate intra-extrac...

Detailed knowledge of the hemodynamics in cerebral aneurysms is valuable not only for understanding their formation and rupture but also for clinical evaluation and treatment. However, important hemodynamic quantities are difficult to measure in vivo. In this paper we present a methodology for modeling patient-specific blood flows in cerebral aneurysms that combines medical image analysis and f...

A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate ...

Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to al...