Land use patterns are the consequence of dynamic processes that often include important legacy issues. Evaluation of past trends can be used to investigate the role of path dependence in influencing future land use through a reference “business as usual” (BAU) scenario. These issues are explored with regard to objectives for woodland expansion in Scotland as a major pillar of climate change pol...

BACKGROUND European studies provide a preponderance of evidence for sublingual allergen immunotherapy (SLIT) safety and efficacy, but they use allergen products that differ from those expected to be approved in the United States. OBJECTIVE To determine the safety and tolerability of 4 US-licensed standardized SLIT allergenic extracts. METHODS Adults 18 to 50 years old with allergic rhinitis...

a r t i c l e i n f o Construction industry observers tout the use of financial incentives as promoters of motivation and commitment on projects. Yet, little empirical evidence exists concerning their effectiveness. What are the drivers of motivation on construction projects? The reasons that construction project participants are motivated to pursue voluntary incentive goals are examined throug...

BACKGROUND Lisdexamfetamine dimesylate (LDX), a prodrug consisting of d-amphetamine and l-lysine, is being studied in clinical trials of major depressive disorder. Additional drug-drug interaction studies were warranted. OBJECTIVE This study aimed to describe the pharmacokinetics and safety of LDX and venlafaxine extended-release (VXR), alone or combined. STUDY DESIGN The study was an open-...

The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...

The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...

Objective: Pharmacokinetic evaluation of Dimethyl Fumarate (DMF) in the Iranian population wasn’t studied. So, aim this research is validation analytical method and pharmacokinetic properties bioequivalence generic form drug versus reference product. Methods: 2 single-dose, test, DMF products were orally administered to 24 healthy volunteers. The washout period was 28 d between treatments. Mono...

Background: Lamotrigine is an anti-epileptic medicine used to treat epilepsy and bipolar disorder. The mechanism of action block voltage activated sodium channels. aim this study was evaluate the bioequivalence 2 oral formulations lamotrigine 25 mg in healthy volunteers.Methods: A single-dose, two-period, randomized crossover design - Indian adult volunteers conducted at Amaris Clinical, a divi...

The paper presents an analysis of current literature data on the use R-enantiomer α-lipoic acid as antihypertensive treatment in patients with hypertension and metabolic syndrome. An was carried out its antiinflammatory agent inflammatory diseases. Currently, a very important aspect researches is possibility using R-α-lipoic micronutrient therapeutic for diabetic polyneuropathy neurodegenerativ...

Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity. Because of the clinical toxicities associated with chronic Urd administration, the ability of benzylacyclouridine (BAU) to effect, in viv...