BACKGROUND: The phospholipase A2 (PLA2) family comprises multiple isoenzymes that vary in their physicochemical properties, cellular localizations, calcium sensitivities, and substrate specificities. Despite these differences, PLA2s share the ability to catalyze the synthesis of the precursors of the proinflammatory mediators. To investigate the potential of PLA2 as a biomarker in screening neu...

This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer's disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer's disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was n...

Gliomas are a group of aggressive brain tumors that diffusely infiltrate adjacent brain tissues, rendering them largely incurable, even with multiple treatment modalities and agents. Mostly asymptomatic at early stages, they present in several subtypes with astrocytic or oligodendrocytic features and invariably progress to malignant forms. Gliomas are difficult to classify precisely because of ...

According to the Merriam-Webster Online Dictionary, a biomarker is ‘a distinctive biological or biologically derived indicator (as a metabolite) of a process, event, or condition (as aging, disease, or oil formation)’ [1]. A biomarker can be structural, such as mammography or a coronary calcium scan, or functional, such as glomerular filtration rate or blood pressure, but the term biomarker is ...

Early cancer detection before metastasis in asymptomatic patients is one of the primary objectives of cancer research initiatives. Early detection generally means more opportunities for intervention that ultimately lead to improvement in patient outcomes. Many studies have concluded that early detection of breast cancer in women older than 50 years with mammogram screening programs improves sur...

Detection of volatile organic compounds in exhaled air is a promising approach to non-invasive and scalable gastric cancer screening. This work proposes new for the detection by analyzing odor-evoked calcium responses rat olfactory bulb. We estimate feasibility biomarker added healthy participants. Our detector consists convolutional encoder similarity-based classifier over outputs. To minimize...

diagnosis of subclinical and early stage clinical periodontal dysfunction could prevent from further socioeconomic burden. the aim of this study was to assess the diagnostic applicability of nitric oxide and its end-metabolites in periodontal tissue health and disease. forty-two patients were enrolled and divided into three groups according to gingivitis (gi) and clinical attachment level (cal)...

organophosphate (ops) compounds are widely used in intensive agriculture to improve production, protect crops and control diseases vectors. the main mechanism of toxicity of ops is the inhibition of the cholinesterase enzymes. in this study the acetylcholinestrase (ache), butyrylcholinesterase (bche) and specific acetylcholinestrase (sache) activities as potential biomarkers of exposure to ops ...

acute coronary syndrome is the leading cause of mortality worldwide. for prompt diagnosis and management of this disease, several biomarkers have been utilized. recently microrna which are suggestive of tissue damage and some are cardiospecific are paid special attention and might help in dearly diagnosis of this disease and furthermore help in preventing the resultant mortality. in this review...

aim : in the current study, we aimed at identifying independent laboratory parameter to predict liver damage. background : although liver biopsy is frequently recommended in assessing disease severity and selecting antiviral treatment candidates, it has several limitations. patients and methods : a total of 527 patients with untreated chronic hepatitis b virus infection were selected. a percuta...