Optical tomography has been widely investigated for biomedical imaging applications. In recent years optical tomography has been combined with digital holography and has been employed to produce high quality images of phase objects such as cells. In this paper we describe a method for imaging 3D phase objects in a tomographic configuration implemented by training an artificial neural network to...

Optical microscopy has played a critical role for discovery in biomedical sciences since Hooke's introduction of the compound microscope. Recent years have witnessed explosive growth in optical microscopy tools and techniques. Information in microscopy is garnered through contrast mechanisms, usually absorption, scattering, or phase shifts introduced by spatial structure in the sample. The emer...

By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have to sacrifice either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning OR-PAM by u...

Optical tomography has been widely investigated for biomedical imaging applications. In recent years optical tomography has been combined with digital holography and has been employed to produce high-quality images of phase objects such as cells. In this paper we describe a method for imaging 3D phase objects in a tomographic configuration implemented by training an artificial neural network to...

Organic chromophores or crystals with large two-photon absorption (TPA) in the solid state are very much demanded for applications in optical limiting, frequency-upconversion lasing, laser pulse stabilization and reshaping etc. [ 1,2 ] In particular, effi cient two-photon excited fl uorescence emission or absorption that can be achieved at low optical intensity with the near infrared wavelength...

Many biological specimens are transparent and in weak intensity contrast, making it invisible using conventional bright field microscopes. Therefore, the phase-based optical microscopy techniques play important roles in the development of the modern biomedical science. Furthermore, the ability to achieve quantitative phase measurement of the tiny structures of biomedical specimens is of great i...

According to the NIH roadmap, optical molecular imaging has an instrumental role in the development of molecular medicine. Great efforts, including those with bioluminescent imaging techniques, have been made to understand the linkage between genes and phenotypic expressions in normal and disease biology. Currently, bioluminescent techniques are widely used in small animal studies. However, mos...

Photoacoustic tomography (PAT) is new imaging modality for visualizing the optical absorption coefficient of a probe. It has proven great promise for a variety of biomedical applications, such as imaging of animals, early cancer diagnostics, and imaging of vasculature (see [9, 21, 27, 30, 38, 39, 40, 43]). PAT is based on the excitation of acoustic pressure waves by illuminating a probe with sh...

Polarization sensitive optical coherence tomography (PS-OCT) is an imaging technique based on light scattering. PS-OCT performs rapid twoand three-dimensional imaging of transparent and translucent samples with micrometer scale resolution. PS-OCT provides image contrast based on the polarization state of backscattered light and has been applied in many biomedical fields as well as in non-medica...

A 2D ultrasound field imaging system that uses a CCD array to map the optical output of a planar Fabry-Perot polymer film sensing interferometer is described. This system enables ultrasound fields to be rapidly mapped over a 6.6 4.7 mm aperture with spatial and temporal resolutions of the order of 10 mm and 10 ns, respectively. The concept was successfully demonstrated by imaging the acoustic f...