In addition to its genetic function, DNA is one of the most distinct and smart self-assembling nanomaterials. DNA nanotechnology exploits the predictable self-assembly of DNA oligonucleotides to design and assemble innovative and highly discrete nanostructures. Highly ordered DNA motifs are capable of providing an ultra-fine framework for the next generation of nanofabrications. The majority of...

In the recent years many types of biosensors have been developed and used in a wide variety of analytical settings with applications in biomedicine, health care, drug design, environmental monitoring, detection of biological, chemical and toxic agents etc. In the field of sensor research and development, bionanotechnology is poised to make significant contributions and has the potential to radi...

A practically simple top-down process for the exfoliation of graphene (GN) and few-layer graphene (FLG) from graphite is described. We have discovered that a biocompatible amphiphilic pyrene-based hexahistidine peptide is able to exfoliate, functionalize, and dissolve few layer graphene flakes in pure water under exceptionally mild, sustainable and virtually innocuous low intensity cavitation c...

The ability to modify peptide- and protein-based biomaterials selectively under mild conditions and in aqueous buffers is essential to the development of certain areas of bionanotechnology, tissue engineering and synthetic biology. Here we show that Self-Assembling peptide Fibers (SAFs) can incorporate multiple modified peptides non-covalently, stoichiometrically and without disrupting their st...

During the last decade, arrays of exploratory experiments conducted to gauge the solid impact of nanotechnology have comparatively proved its efficiency. Nanoparticles (Nps) are solid particles with dimensions between 1 to 100 nm. At present, Copper (Cu) nanoparticles find wide applications in agricultural, industrial engineering and technological fields. In agriculture much effort has been mad...

Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical condition...

Nanotechnology is the engineering of purposeful systems at the molecular scale. It has an impact on every industry counting semiconductors, manufacturing, and biotechnology. Biomedical nanotechnology, bionanotechnology and nanomedicine are increasing biomedicine offered hybrid fields. The oncoming generations of nanoscale biomedical/pharmaceutical products will have object specificity, carry mu...

BACKGROUND Subunit number is amongst the most important structural parameters that determine size, symmetry and geometry of a circular protein oligomer. The L-tryptophan biosynthesis regulator, TRAP, present in several Bacilli, is a good model system for investigating determinants of the oligomeric state. A short segment of C-terminal residues defines whether TRAP forms an 11-mer or 12-mer asse...

POLYMERIC NANOCARRIERS AND THEIR ORAL INHALATION FORMULATIONSFOR THE REGIONAL DELIVERY OF NUCLEIC ACIDS TO THE LUNGSbyDENISE SANTOS CONTIDecember 2013Advisor: Dr. Sandro R. P. da RochaMajor: Chemical EngineeringDegree: Doctor of PhilosophyGene therapy has attracted attention in the fields of medicine, pharmacy, andbionanotechnology due to the potential fo...

Amyloid fibrils are fibrillar polypeptide aggregates consisting of a cross-b structure. The rigidity and stability of these fibrils contributes to their natural pathogenicity or functionality and has suggested potential applications in bionanotechnology. Yet, amyloid fibrils can occur in different morphologies with unique mechanical and flexible characteristics. Herein, we use electron cryo-mic...