*Molecular Medicine Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan; Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Pharmaceutical Chemistr...

The development of therapeutics is costly, time-consuming and has high attrition rates. Biopharmaceutical medications differ from traditional agents in their discovery, design, structure and formulation. Prior to marketing a drug must show efficacy and acceptable toxicity in both preclinical and clinical trials. Regulatory bodies have a pivotal role in the licensing, naming and marketing of an ...

Department of Biopharmaceutical Sciences (T.D.N., J.M.G., L.W.C., L.K., A.S., K.M.G., D.L.K.), Program in Human Genetics (K.M.G., D.L.K.), and Department of Pharmaceutical Chemistry (C.C.H., D.S., M.K., S.J.J., T.E.F.) and Genomics Core Facility, Program in Human Genetics (E.J.C., T.T.), University of California, San Francisco, San Francisco, California; and Department of Molecular and Cell Bio...

Anti-tumor effect of Doxorubicin with Bubble Liposome and Ultrasound Yoshinori Ueno1, Syozo Sonoda2, Ryo Suzuki3, Masahiro Yokouchi1, Yasuomi Kawasoe1, Kazuo Maruyama3, Taiji Sakamoto2, Setsuro Komiya1 1Department of Orthopaedic Surgery, kagoshima Graduate School of Medicine and Dental Sciences, Kagoshima, Japan; 2Department of Ophthalmology, kagoshima Graduate School of Medicine and Dental Sci...

This application note describes how the Agilent Bio-Monolith Protein A column was applied to the optimization of Chinese hamster ovary cell-culture conditions to produce a recombinant monoclonal antibody with desired structural characteristics, focusing on glycosylation. The workflow demonstrates the versatility and wide applicability of the column in biopharmaceutical and biosimilar development.

Xingmei Han, Gene Lee, Colleen Hefner, Jacquelyn J. Maher, and Maria Almira Correia Departments of Cellular & Molecular Pharmacology (XMH, MAC), Pharmaceutical Chemistry (MAC), Biopharmaceutical Sciences (MAC), and Medicine (GL, CH, JJM) and The Liver Center (XMH, MAC, GL, CH, JJM), University of California, San Francisco, CA 94143 JPET Fast Forward. Published on March 15, 2005 as DOI:10.1124/j...

Mammalian cells dominate the biopharmaceutical industry and maintaining cell viability is a limiting factor in most mammalian cell cultures. This project is focused on developing an online (in-situ) dielectric spectroscopy sensor that is capable of measuring cell viability in real-time to enable optimization of culture conditions for Chinese Hamster Ovary (CHO) cell lines in micro-bioreactors.

www.ondrugdelivery.com 27 In this article, Mahesh Chaubal, PhD, Senior Director, Drug Development, R&D Medical Products, Baxter Healthcare Corporation, provides a glimpse of some of the challenges faced during the development of viscous formulations of biopharmaceutical products for injection, from a formulator’s perspective, especially when the finished product is filled in a prefilled syringe...

Calorimetric investigations of systems of pharmaceutical interest are selectively reviewed. Attention is drawn to the need for more systematic and quantitative investigations of bioactivity, especially of synergic and antagonistic drug combinations. Formulation affects biological response (BR) and hence attention is given in this review to some of the factors that may be of biopharmaceutical im...