The membrane of a cell, often compared to dynamic city border, carries out an intricate dance controlling entry and exit, guarding the valuable life processes occurring inside [...]

Abstract Fluidic force microscopy (FluidFM), which combines atomic (AFM) with microchanneled cantilevers connected to a pressure controller, is technique allowing the realization of force-sensitive nanopipette under aqueous conditions. FluidFM has unique advantages in simultaneous three-dimensional manipulations and mechanical measurements biological specimens at micro-/nanoscale. Over past dec...

1 Manager, Clinical Physics, London Regional Cancer Centre and Professor, Oncology, Medical Biophysics, Physics and Astronomy, Diagnostic Imaging, University of Western Ontario 2 Senior Physicist and Tomotherapy Project Coordinator, London Regional Cancer Centre and Associate Professor, Oncology, Medical Biophysics, University of Western Ontario 3 Medical Director, Radiation Treatment Program, ...

The kinetics of Mnoxalate formation and decay were investigated in reactions catalyzed by manganese peroxidase (MnP) from the basiomycete Ceriporiopsis subvermispora in the absence of externally added hydrogen peroxide. A characteristic lag observed in the formation of this complex was shortened by glyoxylate or catalytic amounts of Mn or hydrogen peroxide. MnP titers had a minor effect on this...

In this issue, Lee et al. report the experimental temperature-dependence of the unzipping force for two natural DNA sequences. For both sequences, the curves show an anomaly at temperatures around 40 degrees C. In this brief contribution, we stress that the anomaly is not easily explained within the established theoretical models for the biophysics of DNA. As this puzzle questions our basic und...