Anthropogenic forces, such as petroleum spills and the incomplete combustion of fossil fuels, have caused an accumulation of petroleum hydrocarbons in the environment. The accumulation of petroleum and its derivatives now constitutes an important environmental problem. Biocatalysis introduces new ways to improve the development of bioremediation strategies. The recent application of molecular t...

As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested aga...

Here we report the 8 Mb high quality draft genome of Streptomyces sp. strain AW19M42, together with specific properties of the organism and the generation, annotation and analysis of its genome sequence. The genome encodes 7,727 putative open reading frames, of which 6,400 could be assigned with COG categories. Also, 62 tRNA genes and 8 rRNA operons were identified. The genome harbors several g...

†These authors have contributed equally to this work. The enormous potential in diversity of the marine life is still not fully exploited due to the difficulty in culturing many of the microorganisms under laboratory conditions. In this mini-review we underlined the importance of using an omics technique, such as metagenomics, to access the uncultured majority of microbial communities. We repor...

The contribution of traditional knowledge to modern medicine has been recognized as it provides valuable clues the scientific community for drug discovery. Although western science was reluctant recognize its until recently, there is growing interest in recent years. There are well-established cases from around world that have led also a huge potential explore this area Nepal. In short communic...