Highly selective CYP1B1 inhibitors have potential in the treatment of hormone-induced breast and prostate cancers. Mimicry of potent and selective CYP1B1 inhibitors, α-naphthoflavone and stilbenes, revealed that two sets of hydrophobic clusters suitably linked via a polar linker could be implanted into a new scaffold 'biphenyl ureas' to create potentially a new class of CYP1B1 inhibitors. A ser...

Novel composites of highly ordered and stable biphenyl-bridged periodic mesoporous organosilica (PMO) materials confined within the pores of anodic alumina membranes (AAM) were successfully synthesized by evaporation-induced self-assembly (EISA). 4,40-Bis(triethoxysilyl)biphenyl (BTEBP) was used as a precursor in combination with the ionic surfactant cetyltrimethylammonium bromide (CTAB) or tri...

The aim of this study was to analyze the structural and functional changes occurring in a polychlorinated-biphenyl (PCB)-contaminated soil ecosystem after the introduction of a suitable host plant for rhizoremediation (Salix viminalis). We have studied the populations and phylogenetic distribution of key bacterial groups (Alpha- and Betaproteobacteria, Acidobacteria, and Actinobacteria) and the...

The genes of two 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC1 and BphC2) were obtained from the gene library of Rhodococcus sp. R04. The enzymes have been purified to apparent electrophoretic homogeneity from the cell extracts of the recombinant harboring bphC1 and bphC2. Both BphC1 and BphC2 were hexamers, consisting of six subunits of 35 and 33 kDa as determined by sodium dodecyl sulfate-pol...

Biphenyl dioxygenase (Bph Dox) is responsible for the initial dioxygenation step during the metabolism of biphenyl. The large subunit (BphA1) of Bph Dox plays a crucial role in the determination of the substrate specificity of biphenyl-related compounds, including polychlorinated biphenyls (PCBs). Based on crystallographic analyses of naphthalene dioxygenase (B. Kauppi, K. Lee, E. Carredano, R....

We present two classes of host materials for blue phosphors. The first are carbazole substituted biphenyls 1-9. In these CBP-type materials the triplets are confined to one half of the molecules by using either twisted biphenyls or by a metalinkage of the carbazoles to the biphenyl. We obtained high triplet energies of 2.95-2.98 eV and high glass transition temperatures in the range of 100-120 ...

The title compound, poly[bis-{μ2-4,4'-bis-[(1,2,4-triazol-1-yl)meth-yl]biphenyl-κ2N4:N4'}bis-(nitrato-κO)zinc(II)], [Zn(NO3)2(C18H16N6)2] n , is a two-dimensional zinc coordination polymer constructed from 4,4'-bis-[(1H-1,2,4-triazol-1-yl)meth-yl]-1,1'-biphenyl units. It was synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The ZnII cation is located on a...