Cancer patients with acute venous thromboembolism (VTE) have an increased incidence of recurrences and bleeding complications while on anticoagulant therapy. Methods RIETE is an ongoing registry of consecutive patients with acute VTE. We tried to identify which cancer patients are at a higher risk for recurrent pulmonary embolism (PE), deep vein thrombosis (DVT) or major bleeding. Up to May 200...

von Willebrand disease (VWD) type 1 is difficult to diagnose because of bleeding variability and low heritability of von Willebrand factor (VWF) levels. We compared a bleeding severity score and bleeding times to candidate gene haplotypes within pedigrees of 14 index cases, using a covariance components model for multivariate traits (Mendel: QTL Association). These pedigrees included 13 affecte...

AIM Oral anticoagulants are the most common used substance for treatment and prophylaxis of warfarin venous and arterial thromboembolic disorders in the world. Therapeutic index of warfarin is narrow. CYP2C9 is a hepatic microsomal enzyme and has a primary role in metabolism of warfarin and genetic variations of CYP2C9 may cause a serious effect on the response to warfarin in patients. The aim ...

GOAL To review the literature on the significance, risk factors, and management of occult and gross gastrointestinal (GI) bleeding in patients on antiplatelets and/or anticoagulants. STUDY Relevant original and review articles and their bibliographies were analyzed. Estimates of risks and therapeutic outcomes were obtained from randomized trials, whereas risk factor identification was gathere...

PURPOSE The purpose of study was to compare blood glucose in capillary finger-prick blood and gingival crevice blood using a self-monitoring blood glucose device among patients with gingivitis or periodontitis. METHODS Thirty patients with gingivitis or periodontitis and bleeding on probing (BOP) were chosen. The following clinical periodontal parameters were noted: probing depth, BOP, gingiv...

To investigate the influence of smoking on the response of nonsurical periodontal treatment, at prospective study was carried out on 65 smokers and 68 nonsmoker controls. Both groups were examined periodontally for plaque, bleeding and loss of attachment, before and after a course of treatment with oral hygiene instructions, scaling, root planning periodontal and polishing. Before treatment, me...

Aim: Platelet mass index (PMI) is closely correlated with platelet function in various diseases. In the present study, we aimed to evaluate use of PMI predicting bleeding severity and mortality geriatric patients acute upper gastrointestinal (GI) bleeding. Material Methods: This study a retrospective study. Local ethics committee approval was obtained. It enrolled aged 65 years or older who pre...

Background Oral hygiene is the most essential factor in the prevention and therapy of many diseases, especially the periodontal disease. The aim of this study was to evaluate the oral hygiene-related knowledge, self-efficacy, and motivation of the young adults of rural-based Tamilian population, with their current oral hygiene practices to assess the effect of patient motivation after initial p...

Background The HAS-BLED (hypertension, abnormal renal/liver function, previous stroke, bleeding history or predisposition, labile international normalized ratio [INR], elderly and drugs/alcohol consumption) score has been validated in several scenarios but the recent European guidelines does not recommend any clinical score to assess bleeding risk in atrial fibrillation (AF) patients and only f...

Esthetics plays an important role in dentistry today. Because of an increased emphasis on beauty and health, cosmetic dentistry has been the thrust to the forefront of many practices. Many health products are used for bleaching teeth, but all side effects are not known. Tooth sensitivity and gingival irritation are the most common side effects, but they are typically mild and transient in natur...