A new method has been described for the study in vivo of thrombus formation in blood circulating extracorporeally in an artificial loop. This method permits of control of many factors, and hence of intensive study of thrombus formation under many and varied conditions. It admits of separate study of the formation of white thrombi and of the deposition of fibrin, which may apparently be independ...

BACKGROUND This study was conducted to determine whether replacement of fibrinogen is useful in reversing dilutional coagulopathy following severe haemorrhage and administration of colloids. METHODS In 14 anaesthetized pigs, approximately 65% of the estimated blood volume was withdrawn and replaced with the same amount of gelatin solution to achieve dilutional coagulopathy. Animals were rando...

BACKGROUND AND PURPOSE Hematoma clearance occurs in the days after intracerebral hemorrhage (ICH) and has not been well studied. In the current study, we examined changes in the hematoma in a piglet ICH model. The effect of deferoxamine on hematoma was also examined. METHODS The ICH model was induced by an injection of autologous blood into the right frontal lobe of piglets. First, a natural ...

The stabilization of fibrin clots by activated factor XIII involves two different sets of cross-linked chains. In one case (type I) two gamma-chains are linked to each other, indicating that gamma-chains have both donor (suitable lysyl-) and acceptor (suitable glutaminyl-) functions. A second system (type II) consists of a gamma-chain linked to an alpha-chain. Experiments with a substitute dono...

Bile salt broth containing streptokinase (100 units/ml.) has in our experience proved superior to ordinary bile broth as a culture medium for the isolation of S. typhi from blood clot (Thomas, Watson, and Hewstone, 1954). This superiority refers both to the total number of positive isolations and to the shorter duration of incubation required. In a series of 18 cases (16 typhoid and two paratyp...

Atherosclerosis is a disease caused due to formation of plaque into the artery. Increase in plaque affects the wall shear stress. The present study is performed to calculate wall shear stress in different geometries of stenosed carotid artery. A 2D model of different geometries is generated using CFD for NonNewtonian model. After this WSS of different geometries of stenosed arteries is calculat...

Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole blood is very promising for assessing the complexity of the coagulation system and for global measur...

Blood clot structure plays a role in predisposition to atherothrombotic disease, as compact clots are associated with premature and more severe cardiovascular disease. Some genetic variants of clotting factors have been associated with an increased risk of thrombosis by mechanisms that may involve alteration in clot structure. In addition to genes, environmental factors, such as obesity, diabet...

recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. it has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. thrombophilia is an important predisposition to blood clot formation and is cons...