BACKGROUND Open mouthpiece ventilation is efficacious in patients with neuromuscular disease. We used this ventilation technique in patients with exacerbations of COPD with mild to moderate acidosis. METHODS The study was performed in 2 respiratory monitoring care units. Fifty subjects with exacerbations of COPD, breathing frequency > 25, PaCO2 > 45, and pH between 7.25 and 7.30, as well as K...

UNLABELLED We performed a retrospective analysis to the effects of negative pressure ventilation (NPV), tracheal intermittent positive pressure ventilation (TIPPV), and nasal intermittent positive pressure ventilation (NIPPV, volume or pressure-controlled ventilatory mode), in 114 patients with restrictive ventilatory disorders instituted in our hospital from 1956 until 2005. The patients were ...

BACKGROUND: CO2-pneumoperitoneum used in endoscopic surgery induces system effects by CO2 absorption. This study investigated the effect of the addition of O2 to CO2-pneumoperitoneum, upon CO2 absorption. METHODS: The effect of a pneumoperitoneum using 100% CO2 or 94% CO2 6% O2 upon arterial blood gases, acid base and O2 homeostasis was evaluated. In series A suboptimal ventilation and a pneumo...

OBJECTIVE To assess the efficacy of and patient tolerance for nasal and full-face masks during noninvasive positive-pressure ventilation (NPPV) with patients suffering acute exacerbations of chronic obstructive pulmonary disease. SETTING A respiratory medicine ward of a referral hospital. METHODS Fourteen patients were randomized to 2 groups. Seven used nasal masks and 7 used full-face mask...

A 49 yr old poliomyelitic patient had been under cuirass-type nocturnal negative pressure ventilation for more than 20 yrs. He had a severe restrictive ventilatory impairment, and normal awake blood gases at rest and during light exercise. He was offered a trial of intermittent positive pressure ventilation applied through the nose (nIPPV). Two daytime studies and one night study were carried o...

Estimation of the blood reaction and of blood gases in a series of nineteen individuals suffering from pneumonia failed to reveal a condition of acidosis occurring at any time during the disease. The results of this study are corroborative of a previous one, to which reference has been made.

To assess the physiologic effects of continuous negative extrathoracic pressure (CNEP), negative pressure ventilation (NPV), and negative extrathoracic end-expiratory pressure (NEEP) added to NPV in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD), we measured in seven patients ventilatory pattern, arterial blood gases, respiratory mechanics, and pressure- time p...

High dose buprenorphine is used as substitution treatment in human heroin addiction. Deaths have been reported in addicts using buprenorphine, frequently in association with benzodiazepines. In the current study, we observed the effects of buprenorphine and midazolam alone and in combination on arterial blood gases. Four groups of 10 male Sprague-Dawley rats received a parenteral injection of a...