Alzheimer’s disease (AD), the leading cause of dementia, is a growing health issue with very limited treatment options. To meet need for novel therapeutics, existing drugs additional preferred pharmacological profiles could be recruited. This strategy known as ‘drug repurposing’. Here, we describe dimethyl fumarate (DMF), drug approved to treat multiple sclerosis (MS), tested candidate other br...

Abstract Traumatic brachial plexus injuries are considered to be among the rarest but most debilitating complications of shoulder dislocation. In addition, posterior dislocations also rare, accounting for only 2–4% all dislocations. A 40-year-old female patient presented emergency department (ED) with a dislocated right secondary mechanical fall. Plain film X-rays demonstrated dislocation humer...

The choroid plexus produces cerebrospinal fluid and plays an important role in brain homeostasis both pre and postnatally. In vitro studies have suggested that cells from adult choroid plexus have stem/progenitor cell-like properties. Our initial aim was to investigate whether such a cell population is present in vivo during development of the choroid plexus, focusing mainly on the chick choroi...

1. Abstract 2. Introduction 3. Structure and Functions of Choroid Plexus 3.1. Structure of choroid plexus 3.2. Functions of choroid plexus 3.3. Composition of cerebrospinal fluid 4. Ageing of Choroid Plexus 4.1. Anatomical modifications in ageing 4.2. Functional alterations in ageing 4.3. Modification of cerebrospinal fluid in ageing 5. Choroid Plexus and Alzheimer’s Disease 5.1. Anatomical alt...

22 SAJS VOL. 53 NO. 1 MARCH 2015 Thoracic outlet syndrome (TOS) is controversial in terms of definition, anatomy, aetiology and treatment. The definition of TOS is generally accepted as ‘upper extremity symptoms due to compression of the neurovascular bundle in the area of the neck just above the first rib’.[1] The thoracic outlet, also known as the cervicothoracobrachial junction, consists of ...

PURPOSE To report 3 cases of neurofibromatosis type 1 (NF1) with choroidal nodules associated with retinal microvascular changes imaged with optical coherence tomography angiography (OCTA). METHODS Small case series in 3 NF1 patients. OCTA examinations were performed by a trained examiner (J.J.) after pupillary dilation. A standard scan, centered over the macula measuring 6 × 6 mm and 3 × 3 m...

The choroid plexus epithelium forms the blood-cerebrospinal fluid barrier and accumulates essential minerals and heavy metals. Choroid plexus is cited as being a "sink" for heavy metals and excess minerals, serving to minimize accumulation of these potentially toxic agents in the brain. An understanding of how low doses of contaminant metals might alter transport of other solutes in the choroid...

brachial plexus injury (bpi) is an uncommon complication of median sternotomy capable of causing a permanent or transitory sensitivity and/or motor function impairment in the upper limbs. during a cardiac surgery through sternotomy, for the assessment of the thoracic cage configuration and the site of mediastinal structures, a broader surgical field may be required. if the sternal retractors ar...

introduction: median nerve (mn), one of terminal branches of brachial plexus, is commonly associated with several variations. this research aimed to review the literature related to the variations of mn from axillary region to cubital fossa. methods: we searched google scholar, science direct, springer, and pubmed electronic databases to compile reports related to the variation of mn published ...