The acute toxic effect of different crude oils (heavy crude oil and bonny light crude oil) on embryos of marine medaka Oryzias melastigma was measured and evaluated by exposure to the water-accommodated fraction (WAF) in the present study. The cardiac function of medaka embryos was used as target organ of ecotoxicological effect induced by oil exposure. Results showed that the developing marine...

The present study is designed to evaluate the safety of aqueous: methanolic (40:60) extract Solanum xanthocarpum whole plant (SXWP) by determining its potential toxicity after acute and subacute administration in male wistar albino rats. Medicinal plants might deliver a few organic activities people, but generally very little known about their toxicity. Though, should be overriding criterion se...

background and objectives: there is a profound inclination among people toward consumption of herbs and herbal products. some of these products are harmful while health-promoting potentials of some others should be discovered. in the present study the antibacterial, antioxidant, acute and subchronic and cancer cell toxicity of methanolic and aqueous extracts of rosa damascena mill. was studied....

  Objective(s): The aim of the present study is to determine the effect of Chloramphenicol (CAP) on rat liver and small intestine. Effect of phenobarbital (PB) on CAP toxicity was also investigated.   Materials and Methods:   Rats were received CAP at doses of 0, 200, 400 and 600 mg/kg. Another group was pretreated with 80 mg/kg PB 30 min prior to administration of various doses...

This study was aimed to investigate an acute toxicity and effects of Nelumbo nucifera flower extract (NNFE) on hyperglycemic and hypolipidemic effects in streptozytocin-induced diabetic rats. In vivo acute toxicity study of NNFE was carried out by once oral administration various doses (0, 500, 1000, 1500 and 2000 mg/kg) of the extract to healthy male adult Wistar rats. Sign or symptom of toxic...

The Mirasol PRT System (Gambro BCT, Lakewood, CO) for platelets and plasma uses riboflavin and UV light to reduce pathogens and inactivate white blood cells in donated blood products. An extensive toxicology program, developed in accordance with International Organisation for Standardisation (ISO) 10993 guidelines, was performed for the Mirasol PRT system. Test and control articles for most of ...

There is scarcity of information on the possible mechanisms of pharmaceutical effluent induced genotoxicity and systemic toxicity. This study investigated the genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats. Rats were orally treated with 5-50% concentrations of the effluent for 28 days. At post-exposure, blood, liver, kidney and bone marrow cells were examined for...