Haptoglobin (Hp ) is a haemoglobin binding a-2 globulin in serum. The genetic polymorphism of the protein is controlled by two codominant alleles, Hpl and Hp2 located on the long arm of chromosome-16, among which Hp2 is predominant. Studies have been taken up for association of haptoglobin phenotypes with several diseases. A high frequency of Hp 1-1 phenotypic patterns are found in haemolytic a...

The provision of suitable blood units for patients carrying clinically significant antibodies to high-frequency antigens (HFAs) is a special challenge for blood establishments. Typing of donors and screening for HFA-negative individuals is increasingly performed by genotyping. In this context the selection of the HFAs of interest, the molecular background of some model antigens, and the differe...

psoriasis is an common, chronic, recurrent, inflammatory disease of the skin, characterized by red scaling plaques on the skin surface. the morphology of psoriatic lesions allows classification of the different types of psoriasis that included plaque type, pustular type and erythrodermic type. i have studied the relationship between distribution of rh and abo blood groups in 110 psoriatic patie...

Milk from women with blood type Le(a+) or Le(b+) contains a specific fucosyltransferase not found in the milk of women with blood type Le(a- b-). The enzyme, a guanosine diphosphate L-fucose: N-acetyl-beta-D-glucosaminylsaccharide alpha-4-L-fucosyltransferase is apparently required for the synthesis of the structural determinants of Le(a) and Le(b) specificity, both of which contain fucose in a...

In case of an injury platelets become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the two extremes of an imbalanced hemostasis where patients with hemophilia suffer from severe bleeding and those with thrombosis from unnecessary blood clots that block normal fl...