Background: Nephrotoxicity is a major side effect of aminoglycoside antibiotics, caused by oxidative damage and inflammation. Fucoidan, group sulfated polysaccharides derived from different species brown algae, are well recognized for their antioxidant anti-inflammatory activities. Objectives: In the present study, we aimed to investigate, first time, efficacy fucoidan extracted Sargassum angus...

Abstract Background Some types of antihypertensive drugs may have pleiotropic effects in patients with chronic kidney disease (CKD). However, whether triple combination therapy angiotensin II receptor blockers (ARBs), calcium channel (CCBs), and thiazide diuretics (TZD) confer renoprotective normotensive CKD remains unknown. Thus, we explored this issue using a rat remnant model. Methods Spragu...

Abstract Background and Aims Nod-like receptor family, pyrin domain containing-3 (NLRP3) activation in kidney diseases contributes to aggravating disease progression fibrosis. However, the role of NLRP3 renal aging is not clear. This study was designed identify whether KO mice could be protected from aging. Method counterpart wild-type (WT) were used at different ages (3 months, 12 24 months). ...

Abstract Acute paraquat poisoning resulting from multiple organ failure usually has a high mortality rate. Liver and kidney, as the key oranges of detoxification elimination, their injuries may suppress toxin excretion enhance toxicity in other organs worsen prognosis. Therefore, we intended to explore prognostic value liver kidney function parameters, further evaluate correlation with more sta...

A male named Anwer Jamal, age 45 years, married, visited Clinic Rafaheaam Dawakhana Ajmali on March 29, 2013, with history of glomerulonephritis, inherited renal diseases, hypertension and previously hooked on voltaren 50 (Diclofenic Sodium, 50 mg) and was not on dialysis. Different diagnostic parameters showed the patient was suffering from acute renal failure according to the RIFLE criteria. ...

objective: this study defines the relationship between salivary beta-2 microglobulin (ß2-m) and intensity of uremia in male patients diagnosed with chronic renal failure (crf). materials and methods: in total of 42 males were enrolled in a case-control study. there were 21 cases of crf and 21 control cases. we collected 10cc of saliva plus 5 cc of blood from all patients to determine ß2-m, bloo...

Icariin is recognized as the major bioactive component of Herba Epimedii. The aim of this study was to evaluate the anti-fatigue properties of icariin using a weight-loaded forced swimming test. The mice were randomly divided into four groups, a control group and three icariin treatment groups. The icariin treated groups received different doses of icariin per os (100, 200 and 400 mg/kg of body...

Background. Olea europaea leaf extract (OELE) has potential health benefits and protects against cytotoxicity. This study investigated the possible ameliorative effect of OELE on cisplatin-induced nephrotoxicity in rats. Methods. Rats were assigned into six groups; two groups received 150 mg/kg or 300 OELE, one group a single dose cisplatin (6 mg/kg) IP first day experiment, then starting from ...

Background and Aim Percutaneous endoscopic gastrostomy (PEG) is often associated with early mortality. We therefore investigated factors death after PEG. Methods The present study comprised patients who had undergone PEG between April 2014 March 2020. Patients were divided into two groups: an mortality group died within 1 month of PEG, a non-mortality whose clinical course could be followed for...