Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for patterning, development, and function of the central and peripheral nervous system. Their effects on neural cells are pleiotropic and highly dynamic depending on the stage of development and the local niche. Neural cells display a broad expression profile of BMP ligands, receptors, and transducer molecules. ...

Five streams in catchments with pastoral dairy farming as the dominant land useweremonitored for periods of 7–16 years to detect changes in response to adoption of best management practices (BMPs). Stream water quality was degraded at the start with respect to N, P, suspended solids (SS) and E. coli concentrations, and was typical of catchments with intensive pastoral agriculture land use. Tren...

OBJECTIVE To investigate the role of bone morphogenetic proteins (BMPs) on α-B-crystallin (CRYAB) expression and its physiological consequences on endothelial cells (ECs). APPROACH AND RESULTS We report that the gene encoding for the small heat shock protein, CRYAB, is a transcriptional target of the BMP signaling pathway. We demonstrate that CRYAB expression is upregulated strongly by BMPs i...

TGF-beta superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have demonstrated vital roles for these proteins in somatic and germ cell proliferati...

Transport of phosphorus (P) from agricultural fields to water bodies deteriorates water quality and causes eutrophication. To reduce P losses and optimize P use efficiency by crops, better knowledge is needed of P turnover in soil and the efficiency of best management practices (BMPs). In this review, we examined these issues using results from 10 Swedish long-term soil fertility trials and var...

Bone morphogenetic proteins (BMPs) were discovered and named in 1965 by Marshall Urist, who initially identified the ability of an unknown factor in bone to induce ectopic bones in muscle 1. In the last 45 years, the osteogenic function of BMPs has been extensively examined, mainly using osteoblasts in culture with exogenous treatments of BMPs 2. Based on their potent osteogenic abilities, clin...

BACKGROUND Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMPs and TGF-beta on ET-1 production by human pulmonary microvascular EC (HMVEC-...

Best management practices (BMPs) started in Florida citrus (Citrus spp.) in the 1990s and have evolved to play a major role in production practices today. One of the earliest BMPs in Florida arose from concerns over nitrate-nitrogen concentrations in some surfi cial groundwater aquifers exceeding the 10 mg·L–1 drinking water standard. This occurred in an area of well-drained sandy soils known a...

Index words: Watershed studies Best Management Practices Restoration Remediation Aquatic systems Studies that evaluate the linkages between watershed improvement through Best Management Practices (BMPs) and downstream outcomes are few. Water quality of coastal waters is often impacted by soil and nutrient loss fromwatersheds in agriculture. Mitigation of these impacts is of concern in the Great...

AIMS The expression of bone morphogenetic proteins (BMPs) was analysed in 47 osteosarcomas to determine differences in the expression of BMP subtypes and to correlate expression with response to chemotherapy, in addition to the disease free and overall survival of patients. METHODS The expression of BMPs was examined immunohistochemically in 47 biopsy specimens of osteosarcoma using commercia...