the ionization effects of charged particles produced in neutron interactions for boron neutroncapture therapy are considered here using srim monte carlo code. the estimated values of these effects ina plexiglas acrylic phantom are shown to agree well with the available experimental values in high boronconcentration areas. as expected, the ionization effects from lithium and alpha particles are ...

Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon suffi...

Success of boron neutron capture therapy (BNCT) is dependent on cellular and molecular targeting of sufficient amounts of boron-10 to sustain a lethal (10)B (n, alpha) (7)Li capture reaction. The purpose of the present study was to determine the efficacy of boronated epidermal growth factor (EGF) either alone or in combination with boronophenylalanine (BPA) as delivery agents for an epidermal g...

A number of nucleoside mono- and diphosphites and phosphonates containing 1,2-dicarbadodecaborane (12) (la-6b) at 5'-position of the sugar moiety have been synthesized in good yields. Experimental details along with the spectroscopic and analytical data, supporting the formation of the title compounds, are presented. These constitute a new generation of boron compounds that are envisioned to be...

Accelerator-based neutron sources are an attractive alternative to nuclear reactors for providing epithermal neutron beams for Boron Neutron Capture Therapy. Based on clinical requirements and neutronics modeling the use of proton and deuteron induced reactions in 7Li and 9Be targets has been compared. Excellent epithermal neutron beams can be produced via the 7Li(p,n)7Be reaction at proton ene...

BNCT is a radiotherapy modality based on the neutron capture and fission reactions that occur when boron-10 is irradiated by thermal neutrons. This reaction generates alpha and lithium that produce high density of ionizations in close to the reaction site. The concept provides high absorbed doses into the cancerous cells preserving the adjacent healthy tissues. Nowadays, the available neutron s...