During the last decade, our view on the skeleton as a mere solid physical support structure has been transformed, as bone emerged as a dynamic, constantly remodeling tissue with systemic regulatory functions including those of an endocrine organ. Reflecting this remarkable functional complexity, distinct classes of humoral and intracellular regulatory factors have been shown to control vital pr...

cedure is quite simple. I should mention here that general practice, in spite of there being a specialist training, is in a poor way. There is a great shortage of GPs, particularly in country areas and some suburbs, and the average age of existing GPs is high. Possibly a British doctor prepared to work hard in areas regarded as medically less attractive by his German colleagues would be given c...

microRNAs have evolved as important regulators of multiple biological pathways essential for bone homeostasis, and microRNA research has furthered our understanding the mechanisms underlying health disease. This knowledge, together with finding that active or passive release from cells into extracellular space enables minimal-invasive detection in biofluids (circulating miRNAs), motivated resea...

Abstract The pediatric musculoskeletal system differs from the adult in many ways, including anatomical, physiological, and psychological differences. These differences will result clinical radiological presentation. In this chapter specific knowledge essential for radiologists who deal with diseases children be discussed a focus on: (a) hip pathologies, (b) infectious inflammatory diseases, (c...

Accurate measurements of physical characteristics of bone are essential for diagnosis, assessment of change following treatment, and therefore, indirectly, for evaluation of new forms of therapy. This is particularly true of osteoporosis and aging skeleton, in which fractures occur easily. Methods: In this study an ultrasonic system was set-up and calibrated on Plexiglas tubes of variable thick...

hemophagocytic syndrome is a non-malignant process that is characterized clinically by fever, hepatomegaly, splenomegaly, pancytopenia in peripheral blood, and reactive histiocytes in the bone marrow. bacterial infectious diseases like typhoid fever and brucellosis and viral infections including cmv, herpes viruses, and epstein-barr virus are diagnosed as the cause of this syndrome. in this pap...

Bone tumors are deadly and incurable diseases that invade large areas of bone, resulting in bone defects. Traditional therapies combining surgery, chemotherapy, radiation have reached their limit efficacy, motivating efforts to develop new therapeutic methods. Fortunately, the development biomaterials provides innovative options for tumor treatment. Suitable capable simultaneously providing the...

Rare bone diseases account for 5% of all birth defects and can cause significant morbidity throughout patients' lives. Significant progress is being made to elucidate the pathophysiological mechanisms underlying these diseases. This paper summarizes presentation highlights of a workshop on Rare Skeletal Diseases convened to explore how the study of rare diseases has influenced the field's under...

conclusion there are significant differences between vo by different microorganisms that help physician to start empirical medical treatment while waiting to definite diagnosis by blood culture, culture from paravertebral abscess, serology and bone biopsy. spinal osteomyelitis is an uncommon cause of back pain but it has potential to compromise nervous system and even death may occur if it is n...

background: celiac disease (cd), as an autoimmune disease has initiated since ingestion of food containing gluten. constant intolerance to gluten causes damages of the small intestinal mucosa. one reason of mal-absorption in children and infants is cd. additionally, about 75% of newly identified patients with cd have low bone mineral density (bmd). many factors have role in metabolic bone disea...