Currently several studies are being carried out on various properties of mesenchymal stem cells (MSCs)however there are a few investigations about drug metabolizing properties of these cells. The aim of thisstudy was to measure the key factors involved in drug metabolism in human bone marrow MSCs. For thispurpose, cellular glutathione (GSH), glutathione Stransferase (GSTs) and...

I n the past 5 years, accumulating evidence has demonstrated plasticity of bone marrow– derived cells. Bone marrow–derived cells display the capacity to change their fate, differentiating into hepatocytes, endothelial cells, muscle cells, and cardiomyocytes, and even neurons. The findings that bone marrow cells differentiate into neurons in vitro and in vivo challenge previous assumptions that ...

Osteoblasts, osteoclasts, chondrocytes, and macrophages that participate in the bone repair process are derived from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). However, the roles of these stem cells during the repair of injured bone tissue are still unclear. In the present study, we examined the effects of bone defect on HSCs and MSCs in bone marrow and spleen in 75 mice...

Bone marrow hosts variety of tissues including hematopoietic lineage cells and mesenchymal stem cells (MSCs). The hematopoietic cells are the major source of the blood cells in the adult body which are regulated within the microenvironment of the stromal cells of the bone marrow [1]. MSCs are multipotent cells and can be differentiate into various cell lineage depend upon their environment and ...

Mesenchymal stem cells isolated from rats are frequently used for tissue engineering research. However, considerable differences have been identified between rat mesenchymal stem cells and those derived from humans, and no defined panel of markers currently exists for the isolation of these cells. The aim of this study was to examine the effects of cell sorting for CD29+/CD90+ cells from rat ad...

Bone marrow stem cells participate in tissue repair processes and may have roles in skin wound repair. Diabetes is characterized by delayed and poor wound healing, and type 1 diabetes seems to lead to stem cell dysfunction. Hence, stem cell dysfunction could contribute to poor healing, and stem cell–based therapies may be efficacious in diabetic wounds. We investigated the potential of exogenou...

s:3604:"During pregnancy, the placenta delivers "cord blood" to the baby through the umbilical cord serving as a lifeline of nourishment from the mother to baby. At birth, "cord blood" remains in the umbilical cord and placenta and until recently, had typically been discarded. The tragedy of this practice is that "cord blood" contains very special cells called "stem cells". Recent advances in m...

Background: Adipose-derived stem cells (ADSC) could be an appealing alternative to bone marrow stem cells (BMSC) for engineering cell-based osteoinductive grafts. Meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. Therefore, we assayed and compared the melatonin effect on osteogenic differentiation of BMSC with that of ADSC. Methods: Mesenchymal...