Bone marrow transplantation is the only cure for sickle cell disease but this curative therapy unfortunately lead to complication and several times death. indicated patients with severe who have complications including strokes, acute chest syndrome, recurrent pain crisis exchange transfusions, nephropathy retinopathy, osteonecrosis of multiple joints priapism. All are not eligible bone due asso...

Bone marrow transplantation (BMT) has become an accepted form of therapy for the treatment of a broad range of haematological, immunological, and inherited metabolic diseases. ~-4 In many cases it offers the opportunity for cure in previously incurable disease states. Examples include refractory leukaemias, aplastic anaemia, primary immunodeficiency syndromes, several inborn errors of metabolis...

Among 380 bone marrow transplant (BMT) recipients, five cases (1.3%) of clonorchiasis were observed from 1991 to 1996. Clonorchis sinensis infection was evident in the results of stool examinations performed for screening purposes 7 days before bone marrow transplantation. Salmonella species were isolated concomitantly from the stools of two of the five patients. None of the patients had sympto...

Increasingly, bone marrow transplant (BMT) is the treatment of choice for certain hematologic diseases. BMT is, however, a risky procedure with many potentially serious complications. Some complications are the result of the conditioning regimen, a stage of transplantation that includes large doses of chemotherapy and/or radiation therapy. Conditioning-induced neutropenia and thrombocytopenia o...

The usual fellowship program entails a 3-yr training period with at least 12 months devoted to clinical training and the remainder devoted primarily to research. In some cases, a 2-yr period of training is offered. The majority of the clinical months are performed during the first year. Trainees attend a weekly outpatient nephrology clinic and participate in weekend call on a regular basis thro...

Using a murine bone marrow transplantation model, we evaluated the long-term engraftment of retrovirally transduced bone marrow cells in nonmyeloablated hosts. Male bone marrow was stimulated in a cocktail of interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor (SCF) for 48 hours, then cocultured on the retroviral producer line MDR18.1 for an additional 24 hours. Functional transduction of h...