BACKGROUND The carboxy terminal cross linked telopeptide of type I collagen (ICTP) has been put forward as a marker of bone resorption. Patients with alcoholic liver disease may have osteodystrophy. AIMS To assess circulating and regional concentrations of ICTP in relation to liver dysfunction, bone metabolism, and fibrosis. METHODS In 15 patients with alcoholic cirrhosis and 20 controls, h...

Recent advances in understanding the role of bone in the systemic regulation of energy metabolism indicate that bone marrow cells, adipocytes and osteoblasts, are involved in this process. Marrow adipocytes store significant quantities of fat and produce adipokines, leptin and adiponectin, which are known for their role in the regulation of energy metabolism, whereas osteoblasts produce osteoca...

The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60...

OBJECTIVE In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism. The 3-phosphoinositide-dependent protein kinase-1 (PDK1) serves as a major signaling molecule particularly for leptin and insulin in AgRP neurons. We asked whether PDK1 in AGRP neurons also contributes to ...

Different epidemiological studies show the relationship between osteoporosis, cardiovascular disease, and cardiovascular-related mortality. Previously considered as age-related but independent diseases, this review reports emerging data showing the common mechanism of both conditions. The relationship between bone-related proteins such as osteocalcin and osteoprotegerin and vascular disease is ...

Accumulating evidence has shown that bone and glucose metabolism are closely associated with each other. Since the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM), osteoporosis is recently recognized as one of diabetic complications, called DM-induced bone fragility. Previous studies showed that collagen cross-links of advanced glycation end products (AGEs) a...

OBJECTIVE To investigate the long-term effects of three antiarthritics, namely dexamethasone, celecoxib, and methotrexate on the histology and metabolism of intact bone tissue in rats. METHODS Thirty-two 12-week-old healthy female Sprague Dawley rats were randomly allocated into four groups: 1) control (saline, daily); 2) dexamethasone (2 mg/kg, twice weekly); 3) celecoxib (50 mg/kg, daily); ...

the role of parathyroid hormone on stature in major beta-thalassemic patients   gr. moshtaghi kashanian phd 1 , a. ahmadi md2, mm. hayat bakhsh md3   1- assistant professor, dept. of biochemistry, faculty of medicine, university of medical sciences, kerman, iran   2- professor of pediaterics, university of medical sciences, kerman, iran   3- assistant professor of internal medicine, faculty of ...

From the sedimentation and diffusion constant values obtained in a solution containing 1 g./ 100 ml. H substance, and using the determined value of the partial specific volume, the molecular weight was calculated from the usual equation (Svedberg & Pedersen, 1940) giving a value of 320 000. From the same data the frictional ratio f/fo obtained was 4-2. This corresponds to an axial ratio of > 10...