BACKGROUND Bone is a frequent site of metastases in advanced cancer and is associated with significant skeletal morbidity. Current treatment options are aimed at preserving and improving functional independence and quality of life. MATERIALS AND METHODS A review of current literature focusing on diagnostic tools and treatment approaches of bone metastasis in advanced cancer was performed and ...

Epigenetic mechanisms influence molecular patterns important for the bone-metastatic process, and here we highlight the role of WW-domain containing oxidoreductase (Wwox). The tumor-suppressor Wwox lacks in almost all cancer types; the variable expression in osteosarcomas is related to lung-metastasis formation, and exogenous Wwox destabilizes HIF-1α (subunit of Hypoxia inducible Factor-1, HIF-...

Objective: To determine the correlation of 18F-FDG SUV value with bone scintigraphy findings, i.e. uptake Tc-99m in diagnosed cases malignancy sclerotic metastasis.
 Study Design: Prospective longitudinal study.
 Place and Duration Study: Armed Forces Institute Radiology Imaging, Rawalpindi Pakistan, from Sep 2020 to Mar 2021.
 Methodology: This study included 30 patients age 18 ...

breast cancer is the most common cancer in women except skin cancer. the common metastatic sites include lymph node, lung, liver and bone. however, metastasis to the bladder is extremely rare. to our knowledge, this is the first case of breast cancer metastasis to urinary bladder in jordan which is reported. nine years after the initial diagnosis of lobular breast carcinoma, the patient suffere...

Bone is the most common site of breast cancer metastasis and once established, it is frequently incurable. Critical to our ability to prevent and treat bone metastasis is the identification of the key factors mediating its establishment and understanding their biological function. To address this issue we previously carried out an in vivo selection process to isolate murine mammary tumor sublin...

Objective(s): We performed a phase IIa clinical trial of trans-1-amino-3-18Ffluoro-cyclobutane carboxylic acid (anti-18F-FACBC), a synthetic amino acid analog for PET, in patients with metastatic prostate cancer. Methods: The study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. Five patients underwent whole-body PET 5 and 30 min after intra...

Background This study identifies the overall survival status of lung cancer patients with bone metastasis and metastasis patterns. Poor prognostic factors were identified to develop a scoring system for estimating survival period after bone metastasis. Methods A retrospective cohort analysis was performed at Chiang Mai University for the period January 1, 2006 and December 31, 2013. Time-to-e...

PURPOSE To evaluate the effectiveness of limited Magnetic Resonance (MR) images including T1- and diffusion-weighted image (DWI) for monitoring vertebral metastasis in patients with prostate cancer. MATERIALS AND METHODS From July 2014 to November 2016, patients diagnosed with spinal metastasis from prostate cancer using 99mTc bone scintigraphy were enrolled. Regardless of the primary local t...

Background – Metastatic carcinomas can involve bone marrow and may lead to subsequent fibrosis failure. The Bone examination is important in patients diagnosed or on chemotherapy for cancer, who presented with peripheral cytopenia. metastasis of by these tumors a sign advanced stage disease poor prognosis.
 Methods Our study retrospective study, which we reviewed total 702 procedures, out ...

Endometrial stromal sarcoma (ESS) is typically associated with metastasis to the abdomen, pelvis, and lung. We found three case reports of ESS metastasis to the bone (two to the thoracic spine, and one to the parietal bone). Our objective is to review the literature on ESS spinal and intracranial metastases and, report the first case of ESS metastatic to the lumbar paraspinal region and sphenoi...