One of the major challenges in the application of bone substitutes is adequate vascularization and biocompatibility of the implant. Thus, the temporal course of neovascularization and the microvascular inflammatory response of implants of NanoBone (fully synthetic nanocrystalline bone grafting material) were studied in vivo by using the mouse dorsal skinfold chamber model. Angiogenesis, microhe...

A number of factors complicate the treatment of periprosthetic fractures of the proximal femur. These include bone quality, fixation of the stem, relation of the fracture to the stem, healing potential of the bone and the patient's future risk of another fall. Vancouver type B1 fractures are commonly fixed with locking plates, but even though results have improved, complication rate is still ra...

The aim of this study is to compare the metallic and natural fiber reinforced polymer composite bone plates used in humerus fractures. A 3D finite element model was developed to analyze the performance of both types of plates. This study proposed on fabrication of natural fiber powdered material (like Sisal (Agave sisalana), Banana (Musa sapientum) and Roselle (Hibiscus sabdariffa)) Reinforced ...

Mixing implants with differing metallic compositions has been avoided for fear of galvanic corrosion and subsequent failure of the implants and of bone healing. The purpose of this study was to evaluate upper-extremity fractures treated with open reduction and internal fixation with metallic implants that differed in metallic composition placed on the same bone. The authors studied the effects ...

Introduction: The techniques used to fixate osteotomized segments of bone have evolved alongside the treatment of craniosynostosis. The use of nonresorbable metal plates and screws offered a method of rigidly stabilizing repositioned segments of bone. Several reports specify the tendency for these fixation systems to "migrate" transcranially. Methods: We present a unique case of a patient who i...

Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal pattern of skeletal growth plate vascularization and ossification. Although hypertrophic chondrocytes develop normally, apoptosis, vascularization, and ossification are delayed, resulting in progressive lengthening of the growth plate to about eight times normal. After 3 weeks postnatal, aberrant apoptosis, ...

We devised a new method for examining the structural changes that occur in trabecular bone in aging and in osteoporosis. With simultaneous measurement of total perimeter and bone area in thin sections, indirect indices of mean trabecular plate thickness (MTPT) and mean trabecular plate density (MTPD) can be derived, such that trabecular bone volume = MTPD X MTPT. MTPD is an index of the probabi...

INTRODUCTION The pursuit of bone fixation systems capable of affording appropriate stability for osteosynthesis has gone through several stages from the use of metal wires, plates, and screws to the current stage of bioabsorbable systems. In our Pediatric Neurosurgery Service and Craniofacial Surgery Unit we began employing these systems in June 1997. The object of this paper is to present a re...

BACKGROUND Children need physical activity and generally do this through the aspect of play. Active play in the form of organized sports can appear to be a concern for parents. Clinicians should have a general physiological background on the effects of exercise on developing epiphyseal growth plates of bone. The purpose of this review is to present an overview of the effects of physical activit...

This paper reports on an experimental animal study evaluating a method of mandibular reconstruction in dogs using autogenous corticocaneclous bone graft and fibrin glue. Eight animals underwent a resection at the mandibular body and primary reconstruction was carried out using osteosynthesis plates and screws. The defect was bridged with an autogenous particulate bone graft from the anterior il...