by Vsevolod V. Panteleenko Traffic to a web server is unpredictable and very peaky. Such peaks can be up to ten times the average load. To avoid losing or alienating clients, web servers are overbuilt to handle the peak load. Consequently, there are huge investments in local infrastructure at web sites that are significantly underutilized except for infrequent peak periods. This dissertation de...

OBJECTIVE Observe and report seat belt use among children transported in belt-positioning booster seats. DESIGN We conducted a cross-sectional, observational survey of children transported in motor vehicles between 2006 and 2007. While drivers completed a survey reporting the child's age, weight and gender, and the driver's age, gender, race, income, education, and relationship to the child; ...

Cancer research is a rapidly evolving field with new discoveries emerging daily on its biology, prevention, diagnosis, and treatment. In particular, the recent achievement of several key immunotherapy milestones dramatically changed the landscape of cancer treatment. An important advance occurred in 2010, with the US Food and Drug Administration (FDA) approval of the first therapeutic vaccine, ...

BACKGROUND Hepatitis B (HBV) vaccination is an important preventive intervention for HIV-infected population. Data regarding booster HBV vaccine for persons with low HBV surface antibody (sAb) titers after vaccination in this immunocompromised population is lacking. METHODS We randomized 60 HIV-infected subjects lacking HBV protection after completion of 3 doses of HBV vaccine to receive a bo...

PURPOSE The purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7). METHODS Blood samples from a total of 45 subjects (age 12-23 months) were included in the study. Subjects were categorized according to immunization status into three groups as follows: 18 s...

Dear Editor, We read with interest the paper by La Torre et al., 1 which conducted two systematic reviews and a meta-analysis to summarize the results of scientific works about influenza and pneumococcal vaccines in onco-hematological patients. We paid specific attention to influenza vaccine results. The protection rate of H1N1 vaccine resulted in 31% and 30% after the first dose and booster do...

Objectives. To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series. Methods. In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV w...

The efficacy of brief treatments for media-recruited pathological gamblers was tested in a randomized clinical trial design (N = 314). Two self-directed motivational interventions were compared with a 6-week waiting list control and a workbook only control. Brief motivational treatment involved a telephone motivational interview and a mailed self-help workbook. Brief motivational booster treatm...

OBJECTIVE To assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure. DESIGN Serological survey. SETTING Five UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire). PARTICIPANTS Children from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following pe...

This paper describes a novel approach to increase the performance of web sites by changing the network traffic between the client and the web servers. This is achieved by introducing a web booster architecture, which instantaneously decreases the processing cost on a web server for requests to both static and dynamic web resources. It consists of a booster appliance, which pre-processes client ...