The process of atresia is an all-or-none phenomenon in that an entire follicle either undergoes atresia or continues along the developmental pathway. The absence of pockets of atresia adjacent to healthy areas of granulosa cells suggests the existence of a coordinating influence within the entire follicular unit during the process of atresia. Gap junctions interconnect the granulosa cells and t...

McPartlin, J. F., Dickson, J. A. S., and Swain, V. A. J. (1972). Archives of Disease in Childhood, 47, 207. Meconium ileus: immediate and long-term survival. The results of surgery for meconium ileus obstruction (37 cases) at Queen Elizabeth Hospital for Children, London, during the years 1953 to 1970 are presented. The surgical survival was 30% in the years 1953 to 1961, and 70% in the years 1...

Introduction: Neonatal nasal airway obstruction induces various degrees of respiratory distress. The management of this disease, including surgical repair, will depend on the severity and location of the obstruction. We describe here a case of congenital nasal nostril stenosis that required surgical repair for stenting of both nares after coanal atresia repair.   Case Report: A 2 days old femal...

Biliary atresia is a rare birth defect that affects 1 in 12,000 to 1 in 19,500 live births. We used data from the National Birth Defects Prevention Study, a multistate case-control study, to identify potential risk factors for isolated biliary atresia (no additional unrelated major birth defects diagnosed). Infants were identified from eight states from 1997 to 2002, with clinical information a...

OBJECTIVE To investigate mortality, cause of death, survival, and quality of life in all types of cardiac malformation with congenital pulmonary atresia. DESIGN Retrospective analysis. SETTING The resident population of one health region with a single tertiary referral centre. PATIENTS All babies with pulmonary atresia live born in 1980 to 1995. MAIN OUTCOME MEASURES Anatomical classifi...

Introduction Early diagnosis of biliary atresia is very important for better outcome of treatment. Ultrasonography is one of the diagnostic tools for early differentiation of biliary atresia from other causes of neonatal cholestasis. It has been reported that triangular cord sign (TACS) in sonography is a reliable sign for diagnosis of biliary atresia. The aim of this study was to re-assess the...

Unilateral choanal atresia is more common than bilateral cases. Unilateral cases may present later in life with unilateral nasal congestion and mucoid rhinorrhea. Pure bony atresia represents 30% of cases while mixed bony and membranous atresia is more common (70%) [1]. The ideal procedure for management of choanal atresia should restore the normal nasal passage, be safe, prevent damage to any ...

Alagille syndrome may mimic biliary atresia in early infancy. Since mutations in JAG1 typical for Alagille syndrome type 1 have also been found in biliary atresia, we aimed to identify JAG1 mutations in newborns with proven biliary atresia (n = 72). Five biliary atresia patients with cholestasis, one additional characteristic feature of Alagille syndrome and ambiguous liver histology were singl...

Intestinal obstructions resulting from various causes such as Hirschsprung disease, intestinal atresia, meconium ileus, and intussusception are not uncommon in the neonatal period 1, 2) . Most of the intestinal obstructions in the pediatric population result from postoperative adhesion or postinflammatory adhesions or stenosis 5) . However, small bowel obstruction caused by an anomalous congeni...

TO those who illt,c~rc~st themsclvcs l)rim:lrily in the surgical problrms of infancy :llld childhood, there swms to be 110 entl to IICW ideas which can be dcvclopc~l in the ol)erative and post-operative care 01’ children, which lead to smoother convalcsccncc~, decreased morbidity, :\nd lower mort:rIit,y rates. In the field Of pediatric surgery, ho\vevcr, the chillleiige still lies in tlic surgi...