naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

abstract objective: to determine the effects of glycemic level on outcome patients with traumatic brain injury . m e t h od s :   from september 2010 to december 2012, all medical records of adult patients with tbi admitted to the emergency room of laura daniela clinic in valledupar city, colombia, south america were enrolled. both genders between 18 and 85 years who referred during the first 4...

brain foreign bodies and penetrating missile injuries of the brain are familiar topics for iranian physicians, especially after iran and iraq war. but it’s not easily plausible that there is a couple of sewing needles in the cranium of a patient who has not any history of head trauma or penetrating injury. the patient was a 42-year-old man who admitted in neurology ward of mottahari hospital in...

BACKGROUND Brain injury is the most important independent predictor of mortality and morbidity in pediatric trauma. The Glasgow Coma Score (GCS) is the commonly used clinical instrument to assess brain injury. However, the GCS or one of its components is often not applicable in children under a certain age or cannot be computed reliably because of the patient's condition or the circumstances su...

Trauma is a major health problem and is a leading cause of death in the age group 1 – 45 yrs. Head injuries caused or contributed to death in most trauma fatalities. The primary goal of imaging the trauma patient is to quickly and accurately identify treatable lesions before secondary injury to the brain occurs. CT scan is ideally suited to evaluate patients immediately after trauma. Head injur...

The brains from 12 babies up to 21/2 years of age, who died after repeated non-accidental injury to the head, were subjected to detailed neuropathological examination. The nine brains from infants under 5 months showed contusional tears--slit like lesions in the white matter surrounded by astrocytes and associated with evidence of old and recent haemorrhage. The three brains from infants over 5...

It has been nearly 15 years since the suggestion that synaptically released Zn2+ might contribute to excitotoxic brain injury after seizures, stroke, and brain trauma. In the original "zinc-translocation" model, it was proposed that synaptically released Zn2+ ions penetrated postsynaptic neurons, causing injury. According to the model, chelating zinc in the cleft was predicted to be neuroprotec...

BACKGROUND We investigated the neuroprotective properties of levosimendan, a novel inodilator, in an in vitro model of traumatic brain injury. METHODS Organotypic hippocampal brain slices from mouse pups were subjected to a focal mechanical trauma. Slices were treated after the injury with three different concentrations of levosimendan (0.001, 0.01 and 0.1 μM) and compared to vehicle-treated ...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...

background & aim: using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologists and neuroscientists. this short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguistic impairment after acquired brain lesions. the pharmacological principles and mechanisms related to the effects of drugs used in aphasia rehabilitation are point...