Intraoperative radiotherapy (IORT) for breast cancer has challenged the standard external beam radiotherapy (EBRT) and has been shown to be non-inferior for treating early breast cancer in the past decade. Several technologies have been tested for IORT and various randomised controlled trials are still ongoing. Different methods of application of IORT have also been evaluated, from early breast...

Background: This study evaluates the dose distribution of the wedged tangential beam three-dimensionally planned conformal radiotherapy (3D-CRT) compared to the previously used (5 years ago) two-dimensionally (2D-RT) planned radiotherapy of the chest wall for postmastectomy breast cancer patients in Clinical Oncology and Nuclear Medicine Department, Mansoura University. Patients and Methods: Th...

Purpose: To identify genes predicting benefit of radiotherapy in patients with high-risk breast cancer treated with systemic therapy and randomized to receive or not receive postmastectomy radiotherapy

Introduction: Siliconeprosthetic implants are commonlyutilizedfor tissue replacement and breast augmentation after mastectomy. On the other hand, some patients require adjuvant radiotherapy in order to preventlocal-regional recurrence and increment ofthe overall survival. In case of recurrence, the radiation oncologist might have to irradiate the prosthesis.The aim of this study was to evaluate...

Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative and palliative intention in numerous clinical situations from precursor lesions such as ductal carcinoma in situ (DCIS) to advanced breast cancer. This review addresses current controversial...

Radiation therapy represents an important aspect of breast cancer treatment. Application of irradiation reduces the incidence of local disease recurrence and improves overall survival of breast cancer patients. Studies have shown that adjuvant irradiation after breast-conserving surgery has the same result as a mastectomy, so adjuvant radiotherapy enables sparing surgery in breast cancer patien...

INTRODUCTION Breast cancer is a health problem of great magnitude. In recent years we have seen an increasing incidence and decreasing mortality from this disease due to implementation of campaigns for early diagnosis and the effectiveness of existing treatments. For more than a century that we know the evidence that growth and development of some tumours depends in part on hormonal stimuli, an...

The technical developments in radiotherapy and the developments in genomics have led to a considerable change in the treatment and research for early breast cancer patients. Results of meta-analysis demonstrated the impact of radiotherapy on local control and survival, boosting therefore new possibilities of sophisticated radiotherapy approaches to allow further minimizing the late toxicity of ...

t BackgroundBackground Ductal carcinoma in situ (DCIS) of the breast is a disorder that has become moree common since it may manifest as microcalcifications that can be detected by screeningg mammography. Since selected women with invasive cancer can be treated safelyy with breast-conservation therapy it is paradoxical that total mastectomy has remainedd the standard treatment for DCIS. We did ...

Not all clinics have breath-hold radiotherapy available for left-breast irradiation. However intensity-modulated radiotherapy (IMRT) has also been advocated as a means of lowering heart doses. There is currently no large-scale, long-term follow-up data after breast IMRT and, since dose distributions may differ from classic tangent-based radiotherapy, caution is needed to avoid unexpected worsen...