Calcium uptake through the mitochondrial Ca2+ uniporter (MCU) is thought to be essential in regulating cellular signaling events, energy status, and survival. Functional dissection of the uniporter is now possible through the recent identification of the genes encoding for MCU protein complex subunits. Cancer cells exhibit many aspects of mitochondrial dysfunction associated with altered mitoch...

increased metabolic activity in muscle secondary to excessive muscle activity during the uptake phase and shortly before fdg injection is a known phenomenon. we present fdg pet/ct findings in a young male, known case of carcinoma maxilla his scan showed diffuse increased metabolic activity in multiple skeletal muscle groups. there was history of unaccustomed, strenuous sports activity of skiing...

Lactate accumulation in tumors has been associated with metastases and poor overall survival in cancer patients. Lactate promotes angiogenesis and metastasis, providing rationale for understanding how it is processed by cells. The concentration of lactate in tumors is a balance between the amount produced, amount carried away by vasculature and if/how it is catabolized by aerobic tumor or strom...

STUDY OBJECTIVES To determine the relative effectiveness of three interventions designed to increase the uptake of breast screening. DESIGN Randomised controlled trial of a nurse visit with health education (group A), nurse visit without health education (group B), and GP letter (group C). SETTING The area of south east London served by the Butterfly Walk Breast Screening Unit in Camberwell...

PURPOSE Cancer cells have altered metabolism, with increased glucose uptake, glycolysis, and biomass production. This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabolism. EXPERIMENTAL DESIGN Thirty-three breast tumors and six normal breast tissues were analyzed by gene expression microarray and by mass spectrom...

Breast cancer is the most common cause of deaths and the most frequently diagnosed cancer among women worldwide. This study aimed to determine the prevalence of breast cancer screening, specifically on clinical breast examination, and the predictors of its uptake among women in Malaysia. A cross-sectional study was carried out in five selected districts whereby women aged between 20 to 64 years...

The common sites of metastasis of breast cancer are bone, lung, and liver, but gastrointestinal metastasis from breast cancer is rare. We experienced a case of solitary ileal metastasis from breast cancer. A 45-years-old woman presented with melena for several weeks. She showed no other abdominal symptoms. Colonoscopy findings showed an ulcerative mucosal lesion in the terminal ileum, and biops...

Sex hormone dependency of breast cancer was studied in vitro by examining 3H-thymidine uptake into DNA of breast cancer cells. DMBA induced breast cancer of rats, Shionogi carcinoma 115 and Shionogi carcinoma 42 of mice were studied preliminarily. These 3 kinds of rodent breast cancer showed the same sensitivity to both sex hormones in vitro as has been shown biologically. Subsequently, this se...