Benign prostatic hyperplasia (BPH) is the most common age-related disease in men. Here we tested the efficacy of Rapatar, a micellar nanoformulation of rapamycin, in two rat models of BPH: testosterone-induced and sulpiride-induced hyperplasia in ventral lobes and lateral/dorsal lobes, respectively. We found that Rapatar prevented hypertrophic and hyperplastic abnormalities and degenerative alt...

Basal leveis of prolactin (PRL) and estradiol (E,) were studied in 10 adolescents with gynecomastia who were ar stages 11 ro IV of rheir sexual developmenr. In 7 of the 10 patients, the hypophyseal response of PRL ro the administracion of sulpiride was assessed: 5 of rhe 7 received 25 mg i.m., and the remaining 50 rng. i.m. The 10 cases were compared wirh 12 control boys wirhour gynecomastia rn...

I would like to inform you about my clinical observations considering unique combination of antidepressant sulpiride in a low dose and a complex homeopathic remedy based on Krebs cycle components. I observed that this combined therapy works better on depressed patients than either sulpiride or complex homeopathic remedy alone. Therefore I drew a conclusion that those two work sinergistically, e...

Cortico-striato-thalamic (CST) systems are anatomical substrates for many motor and executive functions and are implicated in diverse neuropsychiatric disorders. Electrophysiological studies in rats, monkeys and patients with Parkinson's disease have shown that power and coherence of low frequency oscillations in CST systems can be profoundly modulated by dopaminergic drugs. We combined functio...

Body reactions during chain saw work were studied in 14 subjects. The subjects divided into three groups (control, sulpiride, and propranolol) successively cut down logs with a chain saw for seven minutes. The start of the sawing led to a pronounced increase in heart rate which persisted during the sawing. The groups taking sulpiride and propranolol showed a smaller increase in heart rate compa...

The role of dopamine (DA) in rewarding motivated actions is well established but its role in learning how to avoid aversive events is still controversial. Here we tested the role of D2-like DA receptors in the nucleus accumbens (NAc) and the dorsolateral striatum (DLS) of rats in the learning and performance of conditioned avoidance responses (CAR). Adult male Wistar rats received systemic, int...

Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) season. Because A15 neurons project to the ARC, we performed three experiments...

Temporal changes in the avoidance responses and serum prolactin levels were investigated for a 360 min period after s.c. administration of antipsychotic drugs such as chlorpromazine (2 mg/kg), prochlorperazine (2 mg/kg), haloperidol (0.035 mg/kg), droperidol (0.03 mg/kg), YM-09151-2 (0.005 mg/kg) and sulpiride (80 mg/kg) in rats. Male adult rats of the Wistar strain were trained under a continu...