Allergic asthma is characterized by airway inflammation in response to chronic allergen exposure, resulting in remodeling of the airway wall accompanied by dysfunctional airway physiology. However, a link between the immune-inflammatory response to allergen and changes to airway structure and physiology has not yet been fully elucidated. Moreover, the impact of inhaled corticosteroids and beta(...

Chronic bronchial disease constitutes a significant, yet underdiagnosed, cause of both chronic cough, episodic as well as, acute-onset respiratory distress in the adult dog. Untreated, chronic bronchial disease is a debilitating, progressive respiratory syndrome that characteristically results in decreased exercise tolerance, inactivity, paroxysmal respiratory distress, airway collapse, and eve...

Diverticulosis of the bronchial wall was found in patients not only with, but also without, chronic obstructive lung disease; it appeared to start as submicroscopic depressions and dilatations of the ducts of the bronchial gland on the mucosal surface. Multiple depressions and dilatations fused to form a diverticulum which herniated between and through the smooth-muscle cellular bundles. Ruptur...

For in vitro studies of airway pathophysiology, primary epithelial cells have many advantages over immortalised cell lines. Nasal epithelial cells are easier to obtain than bronchial epithelial cells and can be used as an alternative for in vitro studies. Our objective was to compare nasal and bronchial epithelial cells from subjects with COPD to establish if these cells respond similarly to pr...

Chronic bronchial disease constitutes a significant, yet underdiagnosed, cause of both chronic cough, episodic as well as, acute-onset respiratory distress in the adult dog. Untreated, chronic bronchial disease is a debilitating, progressive respiratory syndrome that characteristically results in decreased exercise tolerance, inactivity, paroxysmal respiratory distress, airway collapse, and eve...

Airway foreign body aspiration in children can lead to accidental death, due the itself or removal procedure. Depending on its location, of be challenging. Here, we present a case successful from left upper lobar bronchus via ventilating bronchoscopy with rigid bronchoscope and Fogarty arterial embolectomy catheter. Tracheobronchial bodies locations that are difficult reach forceps, an acute an...

BACKGROUND The purpose of this study was to examine changes in the airway lumen and parenchyma in relation to lung function in patients with chronic obstructive pulmonary disease (COPD) compared with controls. METHODS We studied 70 patients with COPD and 15 normal subjects. Using reconstructed computed tomography (CT) images, we traced the bronchial trees and reconstructed 3 cm circle images ...

The bronchial mucosa contributes to elastic properties of the airway wall and may influence the degree of airway expansion during lung inflation. In the deflated lung, folds in the epithelium and associated basement membrane progressively unfold on inflation. Whether the epithelium and basement membrane also distend on lung inflation at physiological pressures is uncertain. We assessed mucosal ...

BACKGROUND Studies in cystic fibrosis (CF) generally focus on inflammation present in the airway lumen. Little is known about inflammation occurring in the airway wall, the site ultimately destroyed in end-stage disease. OBJECTIVE To test the hypothesis that inflammatory patterns in the lumen do not reflect those in the airway wall of children with CF. METHODS Bronchoalveolar lavage (BAL) f...

BACKGROUND Airway hyperresponsiveness to non-specific stimuli is one characteristic feature of airway diseases such as bronchial asthma and chronic bronchitis. Until now, studies aiming to demonstrate a relationship between in vivo conditions associated with airway hyperreactivity and in vitro airway responsiveness have been inconclusive. OBJECTIVE Since serum immunoglobulin (Ig) E is believe...