نتایج جستجو برای: brunaueremmettteller bet

تعداد نتایج: 8813  

2013
Gang Li Qianting Yang Yibei Zhu Hong-Rui Wang Xinchun Chen Xueguang Zhang Binfeng Lu

Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells. The exact role of these transcription factors in shaping the memory T cell pool is not well understood, particularly with memory stem T cells. Here, we demonstrate that both T-bet or Eomes a...

2014
Sera Oh Eun Sook Hwang

T-Bet (T-box protein expressed in T cells, also called as TBX21) was originally cloned as a key transcription factor involved in the commitment of T helper (Th) cells to the Th1 lineage. T-Bet directly activates IFN-γ gene transcription and enhances development of Th1 cells. T-Bet simultaneously modulates IL-2 and Th2 cytokines in an IFN-γ-independent manner, resulting in an attenuation of Th2 ...

2009
Michael Wallner Martin Himly Angela Neubauer Anja Erler Michael Hauser Claudia Asam Sonja Mutschlechner Christof Ebner Peter Briza Fatima Ferreira

BACKGROUND Allergic reactions towards the birch major pollen allergen Bet v 1 are among the most common causes of spring pollinosis in the temperate climate zone of the Northern hemisphere. Natural Bet v 1 is composed of a complex mixture of different isoforms. Detailed analysis of recombinant Bet v 1 isoforms revealed striking differences in immunologic as well as allergenic properties of the ...

Journal: :The Biochemical journal 2003
Sylvia Laffer Said Hamdi Christian Lupinek Wolfgang R Sperr Peter Valent Petra Verdino Walter Keller Monika Grote Karin Hoffmann-Sommergruber Otto Scheiner Dietrich Kraft Marc Rideau Rudolf Valenta

More than 25% of the population suffer from Type I allergy, an IgE-mediated hypersensitivity disease. Allergens with homology to the major birch ( Betula verrucosa ) pollen allergen, Bet v 1, belong to the most potent elicitors of IgE-mediated allergies. T1, a cytokinin-inducible cytoplasmic periwinkle ( Catharanthus roseus ) protein, with significant sequence similarity to members of the Bet v...

2017
Wai Tuck Soh Peter Briza Elfriede Dall Claudia Asam Mario Schubert Sara Huber Lorenz Aglas Barbara Bohle Fatima Ferreira Hans Brandstetter

Birch pollen allergy affects more than 20% of the European allergic population. On a molecular level, birch pollen allergy can be linked to the two dominant allergens Bet v 1 and Bet v 2. Bet v 2 belongs to the profilin family, which is abundant in the plant kingdom. Importantly, the homologous plant profilins have a conserved cysteine motif with a currently unknown functional relevance. In par...

Journal: :Molecular cancer therapeutics 2015
Ryan Lenhart Stefan Kirov Heshani Desilva Jian Cao Ming Lei Kathy Johnston Russell Peterson Liang Schweizer Ashok Purandare Petra Ross-Macdonald Craig Fairchild Tai Wong Susan Wee

The BET (bromodomain and extra-terminal) proteins bind acetylated histones and recruit protein complexes to promote transcription elongation. In hematologic cancers, BET proteins have been shown to regulate expression of MYC and other genes that are important to disease pathology. Pharmacologic inhibition of BET protein binding has been shown to inhibit tumor growth in MYC-dependent cancers, su...

Journal: :American journal of respiratory and critical care medicine 2006
Takumi Kiwamoto Yukio Ishii Yuko Morishima Keigyou Yoh Atsuko Maeda Kazusa Ishizaki Takashi Iizuka Ahmed E Hegab Yosuke Matsuno Shinsuke Homma Akihiro Nomura Tohru Sakamoto Satoru Takahashi Kiyohisa Sekizawa

RATIONALE Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poorly understood. OBJECTIVES We therefore examined the effects of GATA-3 or T...

Journal: :Journal of immunology 2007
Marianne Gerstmayr Nicola Ilk Irma Schabussova Beatrice Jahn-Schmid Eva M Egelseer Uwe B Sleytr Christof Ebner Barbara Bohle

An ideal vaccine for allergen-specific immunotherapy of type I allergies should display reduced mediator-releasing capacity, induce maturation of APC, and modify the disease-eliciting Th2-dominated allergen-specific response to a more physiological response. We have previously shown that rSbsC-Bet v 1, the recombinant fusion protein of a bacterial surface (S-layer) protein of Geobacillus stearo...

2014
Christian Seutter von Loetzen Thomas Hoffmann Maximilian Hartl Kristian Schweimer Wilfried Schwab Paul Rösch Olivia Hartl-Spiegelhauer

The major birch pollen allergen Bet v 1 is the main elicitor of airborne type I allergies and belongs to the family 10 of pathogenesis related proteins. Bet v 1 is the most extensively studied allergen and is well characterized on the biochemical and immunological level. However, its physiological function remained elusive. Here we present the identification of quercetin-3-O-sophoroside (Q3OS) ...

Journal: :Journal of immunology 2005
Brandon M Sullivan Ousman Jobe Vanja Lazarevic Kristine Vasquez Roderick Bronson Laurie H Glimcher Igor Kramnik

A sustained CD4+ Th1-dominated type 1 immune response is required to successfully control Mycobacterium tuberculosis infection. Considerable work has demonstrated that the transcription factor, T-bet, is required for IFN-gamma expression and fundamental to the generation of type 1 immunity in multiple cell types. Mice lacking T-bet are susceptible to virulent M. tuberculosis infection. Suscepti...

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