نتایج جستجو برای: brutons tyrosine kinase
تعداد نتایج: 260379 فیلتر نتایج به سال:
The diarylurea is a scaffold of great importance in medicinal chemistry as it present numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti-inflammatory properties. Some diarylureas, serine-threonine kinase or tyrosine inhibitors, were recently reported literature. first to come into the market an anticancer agent was sorafenib, followed by some others. In t...
It was shown previously that OAT3 activity was differentially regulated by protein kinases including MAPK, PKA, and PKC. The present study investigated the short-term effect of tyrosine kinase and phosphatidylinositol 3-kinase (PI3K) on OAT3-mediated organic anion transport in S2 segments of renal proximal tubules. Genistein, a tyrosine kinase inhibitor, and wortmannin, a PI3K inhibitor, inhibi...
Protein tyrosine kinase activity was assayed in a variety of chicken tissues during embryonic development and in the adult. In some tissues protein tyrosine kinase activity decreased during embryonic development; however, in other tissues it remained high throughout development, it contrast to the level of protein tyrosine phosphorylation, which decreased during development. The highest levels ...
Abstract BACKGROUND Glioblastoma is associated with dismal outcomes a survival of 15-18 months. A major challenge in glioblastoma the inability to effectively target glioma stem cells (GSCs) that have capacity for self-renewal. GSCs are resistant radiation and traditional chemotherapy agents. Ibrutinib first-in-class, potent, small-molecule tyrosine kinase inhibitor Bruton’s Tyrosine Kinase (BT...
Cholecystokinin (CCK) is a gastrointestinal hormone that acts through a G protein-coupled receptor to stimulate pancreatic enzyme secretion. In this work, we demonstrate that CCK stimulation of dispersed pancreatic acini results in increased tyrosine phosphorylation of several cellular proteins. This is mediated via a calcium-dependent pathway, also activated by a phenethyl ester analogue of CC...
Constitutively activated tyrosine kinase is a sole reason for chronic myelogenous leukemia (CML) in humans. Normal tyrosine kinase is responsible for phosphorylation, which support division of white blood cell .After reciprocal translocation between 9 and 22 chromosome a fusion protein called constitutively activated tyrosine kinase are formed which increase the number of white blood cell and c...
Cross-linking of Fc gamma RIIIA (CD16) receptor on natural killer (NK) cells induces receptor-associated tyrosine kinase activation and tyrosine phosphorylation of numerous intracellular proteins, including phospholipase C (PLC)-gamma 1, PLC-gamma 2 and the associated zeta chain. Here we report that Vav, a proto-oncogene, also became tyrosine phosphorylated upon stimulation of CD16 in interleuk...
There have been few reports of a response to dasatinib or nilotinib after failure of two prior sequential tyrosine kinase inhibitors. We report the outcome of 82 chronic phase patients who received nilotinib or dasatinib as third-line alternative tyrosine kinase inhibitor therapy. Thirty-four patients failed to respond to nilotinib and were started on dasatinib as third-line tyrosine kinase inh...
Response to tyrosine kinase inhibitors at three months is a predictor for long-term outcome in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. We analyzed 456 newly diagnosed chronic myeloid leukemia patients treated with tyrosine kinase inhibitors to determine their outcome based on their response at six months. Forty-four (10%) patients did not achieve major cytogen...
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