BACKGROUND Gemcitabine is a pyrimidine nucleoside analog that is a commonly used chemotherapeutic agent for unresectable or recurrent biliary tract cancer (BTC). Several molecules involved in gemcitabine metabolism, including human equilibrative nucleoside transporter (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase subunit M1 (RRM1), have been investigated as predictive biomar...

Watermarking is the process of embedding watermarks into an image such that the embedded watermark can be extracted later. Lossy compression attacks in digital watermarking are one of the major issues in digital watermarking. Cheddad et al. proposed a robust secured self-embedding method which is resistant to a certain amount of JPEG compression. Our experimental results show that the self-embe...

This paper proposes a novel image authentication scheme, aiming at tampering detection for block truncation coding (BTC) compressed image. The authentication code is generated by using the random number generator with a seed, and the size of the authentication code is based on the user’s requirement, with each BTC-compressed image block being used to carry the authentication code using the data...

Block Truncation Coding (BTC) is novel digital technique in image processing using which images can be coded efficiently. BTC has played an important role in the sense that many coding techniques have been developed based on it. Its main attraction being its simple underlying concepts and ease of implementation. We perform compression using two level quantizer and proving minimum Peak Signal No...

Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN). Of these, EGF, TGFA, HBEGF, and BTC are thought to be high-affinity ligands, whereas AREG, EREG, and EPGN constitute ...

Two new three-dimensional nickel coordination polymers, [Ni3(BTC)2(4,4'-bpy)2(H2O)5].1.5H2O (1) and [Ni(PDB)(4,4'-bpy)].0.5H2O (2)(4,4'-bpy = bipyridine, BTC = 1,2,4-benzenetricarboxylate, PDB = pyridine-3,4-dicarboxylate), have been synthesized under hydrothermal conditions and characterized by elemental analysis, IR, TGA, and single crystal X-ray diffraction. Both compounds contain 2D scaffol...


 CADTH recommends that Imfinzi should be reimbursed by public drug plans for the treatment of locally advanced or metastatic biliary tract cancer (BTC) if certain conditions are met.
 in combination with gemcitabine plus platinum-based chemotherapy only covered to treat patients BTC who have not received prior treatment. Patients receiving relatively good health (i.e., a performance ...

We employed linear and nonlinear error correction models (ECMs) to predict the log returns of Bitcoin (BTC). The ECM is best model for predicting BTC compared neural network autoregressive in terms RMSE, MAE, MAPE. Using a ECM, we are able understand how affected by other coins. In addition, performed Granger-causality tests on fourteen cryptocurrencies.

The hydrothermal reaction of M(NO3)2.6H2O (M = Ni and Zn) with benzene-1,3,5-tricarboxylic acid (H3btc) and 1,2-bis(1,2,4-triazol-4-yl)ethane (btre) produced the mixed-ligand coordination polymers (MOFs) 3 infinity{[Ni3(mu3-btc)2(mu(4)-btre)2(mu-H2O)2]. approximately 22H2O} (1) and 3 infinity{[Zn3(mu4-btc)2(mu4-btre)(H2O)2].2H2O} (3). The compounds, characterized by single-crystal X-ray diffrac...

Evidence suggests that combined gemcitabine-cisplatin chemotherapy extends survival in patients with advanced biliary tract cancer (BTC). We conducted a systematic review in order to collate this evidence and assess whether gemcitabine-cisplatin efficacy is influenced by primary tumor site, disease stage, or geographic region, and whether associated toxicities are related to regimen. MEDLINE (1...